医康传媒

◇◇◇化学鉴别信息◇◇◇

【RTECS 编号】 AB1925000
【化学名】 Acetaldehyde
【CAS 登记号】 75-07-0
【上次更新时间】 199804
【引用数据项】 117
【分子式】 C2-H4-O
【分子量】 44.06
【维斯韦塞(氏)线的符号】 VH1
【化合物描述】 Tumorigen Mutagen Reproductive Effector Human Primary Irritant
【别名】 * Acetaldehyd * Acetaldehyde * Acetic aldehyde * Acetylaldehyde * Aldehyde acetique * Aldeide acetica * Ethanal * NCI-C56326 * Octowy aldehyd * RCRA waste number U001

◇◇◇卫生公害数据◇◇◇

〖皮肤/眼睛刺激数据〗

【测试类型】 Standard Draize test
【接触途径】 Administration into the eye
【测试物种】 Human
【剂量/时间】 50 ppm/15M
【参考】 JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 28,262,1946
【测试类型】 Open irritation test
【接触途径】 Administration onto the skin
【测试物种】 Rodent - rabbit
【剂量/时间】 500 mgREACTION SEVERITY : Mild
【参考】 UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 12/13/1963
【测试类型】 Standard Draize test
【接触途径】 Administration into the eye
【测试物种】 Rodent - rabbit
【剂量/时间】 40 mgREACTION SEVERITY : Severe
【参考】 UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 12/13/1963
〖急性毒性数据〗
【测试类型】 TCLo - Lowest published toxic concentration
【接触途径】 Inhalation
【测试物种】 Human
【剂量/时间】 134 ppm/30M
【毒性作用】 Lungs, Thorax, or Respiration - other changes
【参考】 JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883- Volume(issue)/page/year: 165,1908,1957
【测试类型】 LD50 - Lethal dose, 50 percent kill
【接触途径】 Oral
【测试物种】 Rodent - rat
【剂量/时间】 661 mg/kg
【毒性作用】 Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - altered sleep time (including change in righting reflex) Lungs, Thorax, or Respiration - dyspnea
【参考】 AGACBH Agents and Actions, A Swiss Journal of Pharmacology. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1969/70- Volume(issue)/page/year: 4,125,1974
【测试类型】 LC50 - Lethal concentration, 50 percent kill
【接触途径】 Inhalation
【测试物种】 Rodent - rat
【剂量/时间】 13300 ppm/4H
【毒性作用】 Behavioral - excitement Lungs, Thorax, or Respiration - dyspnea
【参考】 NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0534485
【测试类型】 LDLo - Lowest published lethal dose
【接触途径】 Intraperitoneal
【测试物种】 Rodent - rat
【剂量/时间】 500 mg/kg
【毒性作用】 Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - other changes
【参考】 JBCHA3 Journal of Biological Chemistry. (428 E. Preston St., Baltimore, MD 21202) V.1- 1905- Volume(issue)/page/year: 152,41,1944
【测试类型】 LD50 - Lethal dose, 50 percent kill
【接触途径】 Subcutaneous
【测试物种】 Rodent - rat
【剂量/时间】 640 mg/kg
【毒性作用】 Behavioral - general anesthetic
【参考】 APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 6,299,1950
【测试类型】 LD50 - Lethal dose, 50 percent kill
【接触途径】 Oral
【测试物种】 Rodent - mouse
【剂量/时间】 900 mg/kg
【毒性作用】 Details of toxic effects not reported other than lethal dose value
【参考】 GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 25(11),57,1981
【测试类型】 LC50 - Lethal concentration, 50 percent kill
【接触途径】 Inhalation
【测试物种】 Rodent - mouse
【剂量/时间】 23 gm/m3/4H
【毒性作用】 Details of toxic effects not reported other than lethal dose value
【参考】 CUTOEX Current Toxicology. (Nova Science Publishers, Inc., 6080 Jericho Turnpike, Suite 207, Commack, NY 11725) V.1 1993- Volume(issue)/page/year: 1,47,1993
【测试类型】 LD50 - Lethal dose, 50 percent kill
【接触途径】 Intraperitoneal
【测试物种】 Rodent - mouse
【剂量/时间】 500 mg/kg
【毒性作用】 Details of toxic effects not reported other than lethal dose value
【参考】 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 36,101,1985
【测试类型】 LD50 - Lethal dose, 50 percent kill
【接触途径】 Subcutaneous
【测试物种】 Rodent - mouse
【剂量/时间】 560 mg/kg
【毒性作用】 Behavioral - general anesthetic
【参考】 APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 6,299,1950
【测试类型】 LD50 - Lethal dose, 50 percent kill
【接触途径】 Administration onto the skin
【测试物种】 Rodent - rabbit
【剂量/时间】 3540 mg/kg
【毒性作用】 Details of toxic effects not reported other than lethal dose value
【参考】 UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 12/13/1963
【测试类型】 LDLo - Lowest published lethal dose
【接触途径】 Subcutaneous
【测试物种】 Rodent - rabbit
【剂量/时间】 1200 mg/kg
【毒性作用】 Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes
【参考】 JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 30,429,1927
【测试类型】 LDLo - Lowest published lethal dose
【接触途径】 Intravenous
【测试物种】 Rodent - rabbit
【剂量/时间】 300 mg/kg
【毒性作用】 Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes
【参考】 JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 30,429,1927
【测试类型】 LC50 - Lethal concentration, 50 percent kill
【接触途径】 Inhalation
【测试物种】 Rodent - hamster
【剂量/时间】 17000 ppm/4H
【毒性作用】 Details of toxic effects not reported other than lethal dose value
【参考】 PEXTAR Progress in Experimental Tumor Research. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.1- 1960- Volume(issue)/page/year: 24,162,1979
【测试类型】 LD50 - Lethal dose, 50 percent kill
【接触途径】 Intratracheal
【测试物种】 Rodent - hamster
【剂量/时间】 96 mg/kg
【毒性作用】 Details of toxic effects not reported other than lethal dose value
【参考】 PEXTAR Progress in Experimental Tumor Research. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.1- 1960- Volume(issue)/page/year: 24,162,1979
【测试类型】 LDLo - Lowest published lethal dose
【接触途径】 Intravenous
【测试物种】 Amphibian - frog
【剂量/时间】 800 mg/kg
【毒性作用】 Behavioral - general anesthetic Cardiac - other changes Lungs, Thorax, or Respiration - other changes
【参考】 JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 30,429,1927
【测试类型】 LC50 - Lethal concentration, 50 percent kill
【接触途径】 Inhalation
【测试物种】 Mammal - species unspecified
【剂量/时间】 20100 mg/m3
【毒性作用】 Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - excitement Lungs, Thorax, or Respiration - dyspnea
【参考】 GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 19(7),54,1975

〖其他多剂量毒性数据〗

【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Oral
【测试物种】 Rodent - rat
【剂量/时间】 18900 mg/kg/4W-C
【毒性作用】 Behavioral - fluid intake Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Blood - other changes
【参考】 FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 26,447,1988
【测试类型】 TCLo - Lowest published toxic concentration
【接触途径】 Inhalation
【测试物种】 Rodent - rat
【剂量/时间】 2217 ppm/6H/4W-I
【毒性作用】 Sense Organs and Special Senses (Olfaction) - tumors Kidney, Ureter, Bladder - urine volume decreased Nutritional and Gross Metabolic - weight loss or decreased weight gain
【参考】 TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 23,293,1982
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Intraperitoneal
【测试物种】 Rodent - rat
【剂量/时间】 12600 mg/kg/9W-I
【毒性作用】 Endocrine - other changes Endocrine - changes in adrenal weight
【参考】 NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB234-882
【测试类型】 TCLo - Lowest published toxic concentration
【接触途径】 Inhalation
【测试物种】 Rodent - hamster
【剂量/时间】 4560 ppm/6H/90D-I
【毒性作用】 Lungs, Thorax, or Respiration - structural or functional change in trachea or bronchi Kidney, Ureter, Bladder - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain
【参考】 AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960- Volume(issue)/page/year: 30,449,1975

〖致肿瘤数据数据〗

【测试类型】 TCLo - Lowest published toxic concentration
【接触途径】 Inhalation
【测试物种】 Rodent - rat
【剂量/时间】 735 ppm/6H/2Y-I
【毒性作用】 Tumorigenic - Carcinogenic by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors
【参考】 TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 41,213,1986
【测试类型】 TCLo - Lowest published toxic concentration
【接触途径】 Inhalation
【测试物种】 Rodent - hamster
【剂量/时间】 2040 ppm/7H/52W-I
【毒性作用】 Tumorigenic - equivocal tumorigenic agent by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors Lungs, Thorax, or Respiration - tumors
【参考】 EJCODS European Journal of Cancer and Clinical Oncology. (Pergamon Press, c/o Elsevier Science, 660 White Plains Rd., Tarrytown, NY 10591) V.17(7)- 25, 1981-89. For publisher information, see EJCAEL Volume(issue)/page/year: 18,13,1982
【测试类型】 TC - Toxic concentration (other than lowest)
【接触途径】 Inhalation
【测试物种】 Rodent - rat
【剂量/时间】 1410 ppm/6H/65W-I
【毒性作用】 Tumorigenic - equivocal tumorigenic agent by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors
【参考】 TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 31,123,1984

〖繁殖数据〗

【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Oral
【测试物种】 Rodent - ratDOSE : 4800 mg/kgSEX/DURATION : female 1-20 day(s) after conception
【毒性作用】 Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - respiratory system Reproductive - Specific Developmental Abnormalities - hepatobiliary system
【参考】 AKYIDF Arukoru Kenkyu to Yakubutsu Izon. Alcohol Studies and Drug Dependence. (Japan Kyoto-furitsu Ika Daigaku Hoigaku Kyoshitsu, 465 Kajii-cho, Hirokoji-agaru, Kawara-machi, Kamigyo-ku, Kyoto, 602, Japan) V.16- 1981- Volume(issue)/page/year: 27,334,1992
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Oral
【测试物种】 Rodent - ratDOSE : 5040 mg/kgSEX/DURATION : female 1-21 day(s) after conception
【毒性作用】 Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - endocrine system Reproductive - Specific Developmental Abnormalities - urogenital system
【参考】 AKYIDF Arukoru Kenkyu to Yakubutsu Izon. Alcohol Studies and Drug Dependence. (Japan Kyoto-furitsu Ika Daigaku Hoigaku Kyoshitsu, 465 Kajii-cho, Hirokoji-agaru, Kawara-machi, Kamigyo-ku, Kyoto, 602, Japan) V.16- 1981- Volume(issue)/page/year: 27,334,1992
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Oral
【测试物种】 Rodent - ratDOSE : 5040 mg/kgSEX/DURATION : female 1-21 day(s) after conception
【毒性作用】 Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
【参考】 AKYIDF Arukoru Kenkyu to Yakubutsu Izon. Alcohol Studies and Drug Dependence. (Japan Kyoto-furitsu Ika Daigaku Hoigaku Kyoshitsu, 465 Kajii-cho, Hirokoji-agaru, Kawara-machi, Kamigyo-ku, Kyoto, 602, Japan) V.16- 1981- Volume(issue)/page/year: 27,334,1992
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Intraperitoneal
【测试物种】 Rodent - ratDOSE : 300 mg/kgSEX/DURATION : female 8-13 day(s) after conception
【毒性作用】 Reproductive - Effects on Newborn - behavioral
【参考】 TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 36,31A,1987
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Intraperitoneal
【测试物种】 Rodent - ratDOSE : 50 mg/kgSEX/DURATION : female 12 day(s) after conception
【毒性作用】 Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
【参考】 DADEDV Drug and Alcohol Dependence. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year: 9,339,1982
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Intraperitoneal
【测试物种】 Rodent - ratDOSE : 100 mg/kgSEX/DURATION : female 12 day(s) after conception
【毒性作用】 Reproductive - Specific Developmental Abnormalities - homeostasis
【参考】 DADEDV Drug and Alcohol Dependence. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year: 9,339,1982
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Intraperitoneal
【测试物种】 Rodent - ratDOSE : 400 mg/kgSEX/DURATION : female 8-15 day(s) after conception
【毒性作用】 Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific Developmental Abnormalities - musculoskeletal system
【参考】 SEIJBO Senten Ijo. Congenital Anomalies. (Nippon Senten Ijo Gakkai, c/o Kinki Daigaku Igakubu Kaibagaku Kyoshitsu, 380 Nishiyama, Sayama-cho, Mirami-Kawachi-gun, Osaka-fu, Japan) V.1-26, 1960-86. For publisher information, see CGANE7. Volume(issue)/page/year: 23,13,1983
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Intraperitoneal
【测试物种】 Rodent - ratDOSE : 600 mg/kgSEX/DURATION : female 8-15 day(s) after conception
【毒性作用】 Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)
【参考】 SEIJBO Senten Ijo. Congenital Anomalies. (Nippon Senten Ijo Gakkai, c/o Kinki Daigaku Igakubu Kaibagaku Kyoshitsu, 380 Nishiyama, Sayama-cho, Mirami-Kawachi-gun, Osaka-fu, Japan) V.1-26, 1960-86. For publisher information, see CGANE7. Volume(issue)/page/year: 23,13,1983
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Intraperitoneal
【测试物种】 Rodent - mouseDOSE : 640 ug/kgSEX/DURATION : female 10 day(s) after conception
【毒性作用】 Reproductive - Specific Developmental Abnormalities - musculoskeletal system
【参考】 TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 27,231,1983
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Intravenous
【测试物种】 Rodent - mouseDOSE : 120 mg/kgSEX/DURATION : female 7-9 day(s) after conception
【毒性作用】 Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
【参考】 JOANAY Journal of Anatomy. (Cambridge Univ. Press, 32 E. 57th St., New York, NY 10022) V.51- 1916- Volume(issue)/page/year: 128,65,1979
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Intravenous
【测试物种】 Rodent - mouseDOSE : 4 gm/kgSEX/DURATION : female 6 day(s) after conception
【毒性作用】 Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - Central Nervous System
【参考】 JOANAY Journal of Anatomy. (Cambridge Univ. Press, 32 E. 57th St., New York, NY 10022) V.51- 1916- Volume(issue)/page/year: 132,107,1981
〖致突变数据〗
【测试类型】 Mutation in microorganismsTEST SYSTEM : Bacteria - Salmonella typhimurium
【剂量/时间】 7880 ug/plate
【参考】 EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972- Volume(issue)/page/year: 21,79,1977
【测试类型】 DNA repairTEST SYSTEM : Bacteria - Escherichia coli
【剂量/时间】 7880 ug/plate
【参考】 EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972- Volume(issue)/page/year: 21,79,1977
【测试类型】 Specific locus test
【接触途径】 OralTEST SYSTEM : Insect - Drosophila melanogaster
【剂量/时间】 180 umol/L/48H
【参考】 MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 222,359,1989
【测试类型】 Sex chromosome loss and nondisjunction
【接触途径】 ParenteralTEST SYSTEM : Insect - Drosophila melanogaster
【剂量/时间】 22500 ppm
【参考】 ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 7,677,1985
【测试类型】 Mutation in microorganismsTEST SYSTEM : Yeast - Saccharomyces cerevisiae
【剂量/时间】 44060 ug/L
【参考】 EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 21,180,1993
【测试类型】 Cytogenetic analysisTEST SYSTEM : Yeast - Saccharomyces cerevisiae
【剂量/时间】 850 mmol/L
【参考】 MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 326,165,1995
【测试类型】 Sex chromosome loss and nondisjunctionTEST SYSTEM : Yeast - Saccharomyces cerevisiae
【剂量/时间】 13 mmol/L
【参考】 EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 21,180,1993
【测试类型】 Sex chromosome loss and nondisjunctionTEST SYSTEM : Mold - Aspergillus nidulans
【剂量/时间】 250 ppm
【参考】 MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 215,187,1989
【测试类型】 DNA damageTEST SYSTEM : Human Lymphocyte
【剂量/时间】 1560 umol/L
【参考】 MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 337,9,1995
【测试类型】 DNA damageTEST SYSTEM : Human Cells - not otherwise specified
【剂量/时间】 3 mmol/L
【参考】 CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 15,985,1994
【测试类型】 DNA inhibitionTEST SYSTEM : Human Cells - not otherwise specified
【剂量/时间】 30 mmol/L
【参考】 CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 45,2522,1985
【测试类型】 Mutation test systems - not otherwise specifiedTEST SYSTEM : Human Cells - not otherwise specified
【剂量/时间】 30 mmol/L
【参考】 CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 45,2522,1985
【测试类型】 DNA inhibitionTEST SYSTEM : Human HeLa cell
【剂量/时间】 10 mmol/L
【参考】 CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 13,2389,1992
【测试类型】 Cytogenetic analysisTEST SYSTEM : Human Leukocyte
【剂量/时间】 1000 ppm/72H (Continuous)
【参考】 TSITAQ Tsitologiya. Cytology. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1959- Volume(issue)/page/year: 20,421,1978
【测试类型】 Sister chromatid exchangeTEST SYSTEM : Human Lymphocyte
【剂量/时间】 1200 umol/L
【参考】 ANYAA9 Annals of the New York Academy of Sciences. (New York Academy of Sciences, 2 E. 63rd St., New York, NY 10021) V.1- 1877- Volume(issue)/page/year: 543,369,1988
【测试类型】 Sister chromatid exchangeTEST SYSTEM : Human Fibroblast
【剂量/时间】 40 umol/L
【参考】 EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945- Volume(issue)/page/year: 34,195,1978
【测试类型】 Mutation in mammalian somatic cellsTEST SYSTEM : Human Fibroblast
【剂量/时间】 5 mmol/L
【参考】 CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 15,985,1994
【测试类型】 Micronucleus testTEST SYSTEM : Rodent - rat Fibroblast
【剂量/时间】 500 umol/L
【参考】 MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 101,237,1982
【测试类型】 Morphological transformationTEST SYSTEM : Rodent - rat Kidney
【剂量/时间】 3 mmol/L/3H
【参考】 EJCODS European Journal of Cancer and Clinical Oncology. (Pergamon Press, c/o Elsevier Science, 660 White Plains Rd., Tarrytown, NY 10591) V.17(7)- 25, 1981-89. For publisher information, see EJCAEL Volume(issue)/page/year: 22,671,1986
【测试类型】 Morphological transformationTEST SYSTEM : Rodent - rat Fibroblast
【剂量/时间】 100 umol/L
【参考】 JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76- Volume(issue)/page/year: 6,811,1980
【测试类型】 DNA damageTEST SYSTEM : Rodent - rat Liver
【剂量/时间】 200 mmol/L
【参考】 TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 42,183,1988
【测试类型】 DNA damage
【接触途径】 InhalationTEST SYSTEM : Rodent - rat
【剂量/时间】 1000 ppm/6H/5D (Continuous)
【参考】 FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 6,541,1986
【测试类型】 DNA damageTEST SYSTEM : Rodent - rat Cells - not otherwise specified
【剂量/时间】 500 mmol/L
【参考】 FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 6,541,1986
【测试类型】 Mutation test systems - not otherwise specifiedTEST SYSTEM : Rodent - rat Cells - not otherwise specified
【剂量/时间】 12500 umol/L
【参考】 TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 83,86,1986
【测试类型】 DNA inhibitionTEST SYSTEM : Rodent - rat Fibroblast
【剂量/时间】 1 mmol/L
【参考】 JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76- Volume(issue)/page/year: 6,811,1980
【测试类型】 Mutation test systems - not otherwise specifiedTEST SYSTEM : Rodent - rat Fibroblast
【剂量/时间】 1 mmol/L
【参考】 JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76- Volume(issue)/page/year: 6,811,1980
【测试类型】 Cytogenetic analysisTEST SYSTEM : Rodent - rat Fibroblast
【剂量/时间】 100 umol/L
【参考】 MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 101,237,1982
【测试类型】 Micronucleus test
【接触途径】 IntraperitonealTEST SYSTEM : Rodent - mouse
【剂量/时间】 95 mg/kg
【参考】 MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 389,3,1997
【测试类型】 Morphological transformationTEST SYSTEM : Rodent - mouse Embryo
【剂量/时间】 10 mg/L
【参考】 ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 4,331,1982
【测试类型】 Sister chromatid exchange
【接触途径】 IntraperitonealTEST SYSTEM : Rodent - mouse
【剂量/时间】 15 ng/kg
【参考】 MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 68,291,1979
【测试类型】 Mutation in mammalian somatic cellsTEST SYSTEM : Rodent - mouse Lymphocyte
【剂量/时间】 4 mmol/L
【参考】 MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year: 3,193,1988
【测试类型】 Cytogenetic analysisTEST SYSTEM : Rodent - hamster Embryo
【剂量/时间】 40 ppm
【参考】 MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year: 3,207,1988
【测试类型】 Sister chromatid exchange
【接触途径】 IntraperitonealTEST SYSTEM : Rodent - hamster
【剂量/时间】 500 ug/kg
【参考】 MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 88,389,1981
【测试类型】 Sister chromatid exchangeTEST SYSTEM : Rodent - hamster Ovary
【剂量/时间】 30 umol/L
【参考】 MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 171,169,1986
【测试类型】 Sex chromosome loss and nondisjunctionTEST SYSTEM : Rodent - hamster Embryo
【剂量/时间】 20 ppm
【参考】 MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year: 3,207,1988
【测试类型】 DNA damageTEST SYSTEM : Mammal - species unspecified Lymphocyte
【剂量/时间】 1 mol/L/30M
【参考】 MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 58,115,1978

◇◇◇综述◇◇◇

ACGIH TLV-CL 45 mg/m3 (25 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 36,101,1985 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 36,101,1985 IARC Cancer Review:Group 2B IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,77,1987 TOXICOLOGY REVIEW EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972- Volume(issue)/page/year: 11,163,1975

◇◇◇美国标准和规章◇◇◇

MSHA STANDARD-air:TWA 100 ppm (180 mg/m3) DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8. Volume(issue)/page/year: 3,10,1973 OSHA PEL (Gen Indu):8H TWA 200 ppm (360 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 200 ppm (360 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 200 ppm (360 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 200 ppm (360 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994

◇◇◇职业接触限量◇◇◇

OEL-ARAB Republic of Egypt:TWA 100 ppm (180 mg/m3) JAN 1993 OEL-AUSTRALIA:TWA 100 ppm (180 mg/m3);STEL 150 ppm (270 mg/m3) JAN 1993 OEL-BELGIUM:TWA 100 ppm (180 mg/m3);STEL 150 ppm (270 mg/m3) JAN 1993 OEL-DENMARK:TWA 25 ppm (45 mg/m3) JAN 1993 OEL-FINLAND:TWA 50 ppm (90 mg/m3);STEL 75 ppm (135 mg/m3) JAN 1993 OEL-FRANCE:TWA 100 ppm (180 mg/m3) JAN 1993 OEL-GERMANY:TWA 50 ppm (90 mg/m3);Carcinogen JAN 1993 OEL-HUNGARY:STEL 25 mg/m3;Carcinogen JAN 1993 OEL-INDIA:TWA 100 ppm (180 mg/m3);STEL 150 ppm (270 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 100 ppm (180 mg/m3) JAN 1993 OEL-THE PHILIPPINES:TWA 200 ppm (360 mg/m3) JAN 1993 OEL-POLAND:TWA 5 mg/m3 JAN 1993 OEL-RUSSIA:STEL 5 mg/m3;Skin JAN 1993 OEL-SWEDEN:TWA 25 ppm (45 mg/m3);STEL 50 ppm (90 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 50 ppm (90 mg/m3);STEL 100 ppm (180 mg/m3) JAN 1993 OEL-TURKEY:TWA 200 ppm (360 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 100 ppm (180 mg/m3);STEL 150 ppm JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV

◇◇◇NIOSH 标准发展和监测数据◇◇◇

【参考】 NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992
【NIOSH 职业性接触鉴定数据】 NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 01038 No. of Facilities: 85 (estimated) No. of Industries: 4 No. of Occupations: 10 No. of Employees: 1745 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 01038 No. of Facilities: 7801 (estimated) No. of Industries: 85 No. of Occupations: 95 No. of Employees: 216533 (estimated) No. of Female Employees: 97770 (estimated)

◇◇◇在美国的情况◇◇◇

EPA GENETOX PROGRAM 1988, Positive: E coli polA without S9; In vitro SCE-nonhuman EPA GENETOX PROGRAM 1988, Positive/dose response: In vitro SCE-human lymphocytes EPA GENETOX PROGRAM 1988, Positive/dose response: In vitro SCE-human EPA TSCA Section 8(b) CHEMICAL INVENTORY EPA TSCA Section 8(d) unpublished health/safety studies On EPA IRIS database EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998 NIOSH CURRENT INTELLIGENCE BULLETIN #55, September 1991 NIOSH Analytical Method, 1994: Acetaldehyde by GC, 2538; by HPLC, 3507 NIOSH Analytical Method, 1994: Aldehydes, screening, 2539 NTP 7th Annual Report on Carcinogens, 1992 : anticipated to be carcinogen OSHA ANALYTICAL METHOD #ID-68

◇◇◇全部数据完毕◇◇◇

益母草	菊花
百合花	西洋参

75-07-0