- 【RTECS 编号】 AB4025000
- 【化学名】 Acetamide
- 【CAS 登记号】 60-35-5
- 【BEILSTEIN 参考号】 1071207
- 【参考】 4-02-00-00399 (Beilstein Handbook Reference)
- 【上次更新时间】 199710
- 【引用数据项】 38
- 【分子式】 C2-H5-N-O
- 【分子量】 59.08
- 【维斯韦塞(氏)线的符号】 ZV1
- 【化合物描述】 Tumorigen Drug Mutagen Reproductive Effector
- 【别名】 * Acetic acid amide * Acetimidic acid * Amid kyseliny octove * Ethanamide * Methanecarboxamide * NCI-C02108
- 【测试类型】 LD50 - Lethal dose, 50 percent kill
- 【接触途径】 Oral
- 【测试物种】 Rodent - rat
- 【剂量/时间】 7 gm/kg
- 【毒性作用】 Details of toxic effects not reported other than lethal dose value
- 【参考】 JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 4,219,1962
- 【测试类型】 LD50 - Lethal dose, 50 percent kill
- 【接触途径】 Intraperitoneal
- 【测试物种】 Rodent - rat
- 【剂量/时间】 10300 mg/kg
- 【毒性作用】 Behavioral - altered sleep time (including change in righting reflex) Behavioral - muscle weakness Lungs, Thorax, or Respiration - dyspnea
- 【参考】 ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 20,1242,1970
- 【测试类型】 LD50 - Lethal dose, 50 percent kill
- 【接触途径】 Subcutaneous
- 【测试物种】 Rodent - rat
- 【剂量/时间】 10 gm/kg
- 【毒性作用】 Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Autonomic Nervous System - smooth muscle relaxant (mechanism undefined, spasmolytic) Cardiac - change in rate
- 【参考】 OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 4,451,1970
- 【测试类型】 LD50 - Lethal dose, 50 percent kill
- 【接触途径】 Intravenous
- 【测试物种】 Rodent - rat
- 【剂量/时间】 12500 mg/kg
- 【毒性作用】 Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Sense Organs and Special Senses (Eye) - lacrimation
- 【参考】 NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 64(1),42S,1968
- 【测试类型】 LD50 - Lethal dose, 50 percent kill
- 【接触途径】 Unreported
- 【测试物种】 Rodent - rat
- 【剂量/时间】 2300 mg/kg
- 【毒性作用】 Details of toxic effects not reported other than lethal dose value
- 【参考】 ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 18,645,1968
- 【测试类型】 LD50 - Lethal dose, 50 percent kill
- 【接触途径】 Oral
- 【测试物种】 Rodent - mouse
- 【剂量/时间】 12900 mg/kg
- 【毒性作用】 Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Sense Organs and Special Senses (Eye) - lacrimation
- 【参考】 NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 64(1),42S,1968
- 【测试类型】 LD50 - Lethal dose, 50 percent kill
- 【接触途径】 Intraperitoneal
- 【测试物种】 Rodent - mouse
- 【剂量/时间】 1 gm/kg
- 【毒性作用】 Details of toxic effects not reported other than lethal dose value
- 【参考】 JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ. Volume(issue)/page/year: 62,911,1979
- 【测试类型】 LD50 - Lethal dose, 50 percent kill
- 【接触途径】 Subcutaneous
- 【测试物种】 Rodent - mouse
- 【剂量/时间】 8300 mg/kg
- 【毒性作用】 Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Autonomic Nervous System - smooth muscle relaxant (mechanism undefined, spasmolytic) Cardiac - change in rate
- 【参考】 OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 4,451,1970
- 【测试类型】 LD50 - Lethal dose, 50 percent kill
- 【接触途径】 Intravenous
- 【测试物种】 Rodent - mouse
- 【剂量/时间】 10 gm/kg
- 【毒性作用】 Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Sense Organs and Special Senses (Eye) - lacrimation
- 【参考】 NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 64(1),42S,1968
- 【测试类型】 LD50 - Lethal dose, 50 percent kill
- 【接触途径】 Intravenous
- 【测试物种】 Rodent - rabbit
- 【剂量/时间】 7500 mg/kg
- 【毒性作用】 Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Sense Organs and Special Senses (Eye) - lacrimation
- 【参考】 NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 64(1),42S,1968
- 【测试类型】 LDLo - Lowest published lethal dose
- 【接触途径】 Intravenous
- 【测试物种】 Bird - chicken
- 【剂量/时间】 33410 mg/kg
- 【毒性作用】 Details of toxic effects not reported other than lethal dose value
- 【参考】 ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 20,1242,1970
- 【测试类型】 TDLo - Lowest published toxic dose
- 【接触途径】 Oral
- 【测试物种】 Rodent - rat
- 【剂量/时间】 431 gm/kg/1Y-C
- 【毒性作用】 Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Nutritional and Gross Metabolic - weight loss or decreased weight gain
- 【参考】 JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC. Volume(issue)/page/year: 3(5-6),149,1980
- 【测试类型】 TDLo - Lowest published toxic dose
- 【接触途径】 Oral
- 【测试物种】 Rodent - mouse
- 【剂量/时间】 517 gm/kg/1Y-C
- 【毒性作用】 Tumorigenic - Carcinogenic by RTECS criteria Blood - tumors Blood - lymphoma, including Hodgkin's disease
- 【参考】 JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC. Volume(issue)/page/year: 3(5-6),149,1980
- 【测试类型】 TD - Toxic dose (other than lowest)
- 【接触途径】 Oral
- 【测试物种】 Rodent - rat
- 【剂量/时间】 546 gm/kg/52W-C
- 【毒性作用】 Tumorigenic - neoplastic by RTECS criteria Liver - tumors
- 【参考】 TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 14,163,1969
- 【测试类型】 TDLo - Lowest published toxic dose
- 【接触途径】 Oral
- 【测试物种】 Rodent - rabbitDOSE : 39 gm/kgSEX/DURATION : female 6-18 day(s) after conception
- 【毒性作用】 Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
- 【参考】 ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 30,1557,1980
- 【测试类型】 TDLo - Lowest published toxic dose
- 【接触途径】 Oral
- 【测试物种】 Rodent - rabbitDOSE : 13 gm/kgSEX/DURATION : female 6-18 day(s) after conception
- 【毒性作用】 Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
- 【参考】 ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 30,1557,1980
〖致突变数据〗
- 【测试类型】 Morphological transformationTEST SYSTEM : Rodent - rat Embryo
- 【剂量/时间】 5 mg/L
- 【参考】 JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8. Volume(issue)/page/year: 51,799,1973
- 【测试类型】 Micronucleus test
- 【接触途径】 OralTEST SYSTEM : Rodent - mouse
- 【剂量/时间】 3390 umol/kg
- 【参考】 MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 192,141,1987
- 【测试类型】 Mutation test systems - not otherwise specifiedTEST SYSTEM : Rodent - mouse Ascites tumor
- 【剂量/时间】 10 pph
- 【参考】 IDZAAW Japanese Journal of Genetics. Idengaku Zasshi. (Genetics Soc. of Japan, 111 Tanida, Mishima, Shizuoka-ken, Japan) V.1- 1921- Volume(issue)/page/year: 51,53,1976
- 【测试类型】 Morphological transformationTEST SYSTEM : Rodent - hamster Embryo
- 【剂量/时间】 1 mg/L
- 【参考】 IJCNAW International Journal of Cancer. (International Union Against Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland) V.1- 1966- Volume(issue)/page/year: 19,642,1977
- IARC Cancer Review:Animal Sufficient Evidence IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,389,1987 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 7,197,1974 IARC Cancer Review:Group 2B IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987
- OEL-FINLAND;Carcinogen JAN 1993 OEL-GERMANY;Carcinogen JAN 1993
- 【NIOSH 职业性接触鉴定数据】 NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81686 No. of Facilities: 404 (estimated) No. of Industries: 17 No. of Occupations: 21 No. of Employees: 4668 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81686 No. of Facilities: 132 (estimated) No. of Industries: 4 No. of Occupations: 4 No. of Employees: 2074 (estimated) No. of Female Employees: 1148 (estimated)
- EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat; SHE-clonal assay EPA GENETOX PROGRAM 1988, Positive: Cell transform.-mouse embryo EPA GENETOX PROGRAM 1988, Positive: Cell transform.-RLV F344 rat embryo EPA GENETOX PROGRAM 1988, Negative: Host-mediated assay; E coli polA with S9 EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test; Sperm morphology-mouse EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis EPA GENETOX PROGRAM 1988, Inconclusive: E coli polA without S9 EPA TSCA Section 8(b) CHEMICAL INVENTORY EPA TSCA Section 8(d) unpublished health/safety studies On EPA IRIS database EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
◇◇◇化学鉴别信息◇◇◇
◇◇◇卫生公害数据◇◇◇
〖急性毒性数据〗
〖致肿瘤数据数据〗
〖繁殖数据〗
◇◇◇综述◇◇◇
◇◇◇职业接触限量◇◇◇
◇◇◇NIOSH 标准发展和监测数据◇◇◇
◇◇◇在美国的情况◇◇◇
◇◇◇全部数据完毕◇◇◇
