医康传媒

◇◇◇化学鉴别信息◇◇◇

【RTECS 编号】 AB6825000
【化学名】 Acetamide, 2,2-dichloro-N-(beta-hydroxy-alpha-(hydroxymethyl)-p- nitrophenethyl)-, D-(-)-threo-
【CAS 登记号】 56-75-7
【BEILSTEIN 参考号】 2225532
【参考】 4-13-00-02742 (Beilstein Handbook Reference)
【上次更新时间】 199707
【引用数据项】 96
【分子式】 C11-H12-Cl2-N2-O5
【分子量】 323.15
【维斯韦塞(氏)线的符号】 WNR DYQY1QMVYGG
【化合物描述】 Agricultural Chemical Tumorigen Drug Mutagen Reproductive Effector Human Natural Product
【别名】 * Acetamide, 2,2-dichloro-N-(beta-hydroxy-alpha-(hydroxymethyl)-p-nitrophenethyl)- * Acetamide, 2,2-dichloro-N-(2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl)-, (R-(R*,R*))- * Alficetyn * Ambofen * Amphenicol * Amphicol * Amseclor * Anacetin * Aquamycetin * Austracol * Biocetin * Biophenicol * CAF (pharmaceutical) * CAM * CAP * Catilan * Chemicetin * Chemicetina * Chlomin * Chlomycol * Chloramex * Chloramfenikol * Chloramphenicol * D-Chloramphenicol * D-threo-Chloramphenicol * D-(-)-threo-Chloramphenicol * Chloramsaar * Chlorasol * Chlora-tabs * Chloricol * Chlornitromycin * Chloroamphenicol * Chlorocaps * Chlorocid * Chlorocide * Chlorocidin C * Chlorocidin C tetran * Chlorocid S * Chlorocol * Chloroject L * Chloromax * Chloromycetin * Chloromycetny * Chloronitrin * Chloroptic * Chloro-25 vetag * Chlorovules * Cidocetine * Ciplamycetin * Cloramficin * Cloramicol * Cloramidina * Cloroamfenicolo * Clorocyn * Cloromisan * Clorosintex * Comycetin * CPh * Cylphenicol * Desphen * Detreomycine * D-(-)-threo-2-Dichloroacetamido-1-p-nitrophenyl-1,3-propanediol * D-threo-N-Dichloroacetyl-1-p-nitrophenyl-2-amino-1,3-propanediol * D-(-)-threo-2,2-Dichloro-N-(beta-hydroxy-alpha-(hydroxymethyl))-p-nitrop henethylacetamide * D-(-)-2,2-Dichloro-N-(beta-hydroxy-alpha-(hydroxymethyl)-p-nitrophenylet hyl)acetamide * D-threo-N-(1,1'-Dihydroxy-1-p-nitrophenylisopropyl)dichloroacetamide * Doctamicina * Econochlor * Embacetin * Emetren * Enicol * Enteromycetin * Erbaplast * Ertilen * Farmicetina * Fenicol * Globenicol * Glorous * Halomycetin * Hortfenicol * I 337A * Intramycetin * Isicetin * Ismicetina * Isophenicol * Isopto fenicol * Juvamycetin * Kamaver * Kemicetina * Kemicetine * Klorita * Klorocid S * Leukomyan * Leukomycin * Levomicetina * Levomycetin * Loromisin * Mastiphen * Mediamycetine * Micloretin * Microcetina * Mychel * Mycinol * NCI-C55709 * D-(-)-threo-1-p-Nitrophenyl-2-dichloracetamido-1,3-propanediol * D-threo-1-(p-Nitrophenyl)-2-(dichloroacetylamino)-1,3-propanediol * Normimycin V * Novochlorocap * Novomycetin * Novophenicol * NSC 3069 * Oftalent * Oleomycetin * Opclor * Ophthochlor * Otachron * Otophen * Pantovernil * Paraxin * Pentamycetin * Quemicetina * Rivomycin * Romphenil * Septicol * Sificetina * Sintomicetina * Sintomicetine R * Stanomycetin * Synthomycetin * Synthomycetine * Tevcocin * Tifomycin * Tifomycine * Treomicetina * U-6062 * Unimycetin * Veticol

◇◇◇卫生公害数据◇◇◇

〖急性毒性数据〗

【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Oral
【测试物种】 Human - infant
【剂量/时间】 440 mg/kg
【毒性作用】 Behavioral - somnolence (general depressed activity) Gastrointestinal - other changes Nutritional and Gross Metabolic - body temperature decrease
【参考】 JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883- Volume(issue)/page/year: 234,149,1975
【测试类型】 LDLo - Lowest published lethal dose
【接触途径】 Oral
【测试物种】 Human - woman
【剂量/时间】 400 mg/kg
【毒性作用】 Behavioral - coma Vascular - shock Lungs, Thorax, or Respiration - cyanosis
【参考】 JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883- Volume(issue)/page/year: 234,149,1975
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Unreported
【测试物种】 Human - child
【剂量/时间】 250 mg/kg/10D
【毒性作用】 Liver - other changes Blood - hemorrhage Blood - changes in bone marrow (not otherwise specified)
【参考】 CPEDAM Clinical Pediatrics (Philadelphia). (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1962- Volume(issue)/page/year: 14,499,1975
【测试类型】 LDLo - Lowest published lethal dose
【接触途径】 Intravenous
【测试物种】 Human - infant
【剂量/时间】 30 mg/kg/3D-I
【毒性作用】 Cardiac - cardiac output Vascular - BP lowering not characterized in autonomic section
【参考】 JOPDAB Journal of Pediatrics. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63141) V.1- 1932- Volume(issue)/page/year: 103,487,1983
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Intramuscular
【测试物种】 Human - infant
【剂量/时间】 250 mg/kg/2D
【毒性作用】 Vascular - change in plasma or blood volume
【参考】 NEJMAG New England Journal of Medicine. (Massachusetts Medical Soc., 10 Shattuck St., Boston, MA 02115) V.198- 1928- Volume(issue)/page/year: 262,787,1960
【测试类型】 LDLo - Lowest published lethal dose
【接触途径】 Unreported
【测试物种】 Human - infant
【剂量/时间】 200 mg/kg/4D-I
【毒性作用】 Behavioral - convulsions or effect on seizure threshold Blood - eosinophilia Skin and Appendages - dermatitis, allergic (after systemic exposure)
【参考】 LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 1,555,1986
【测试类型】 LD50 - Lethal dose, 50 percent kill
【接触途径】 Oral
【测试物种】 Rodent - rat
【剂量/时间】 2500 mg/kg
【毒性作用】 Details of toxic effects not reported other than lethal dose value
【参考】 FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 10,3,1955
【测试类型】 LD50 - Lethal dose, 50 percent kill
【接触途径】 Intraperitoneal
【测试物种】 Rodent - rat
【剂量/时间】 1811 mg/kg
【毒性作用】 Details of toxic effects not reported other than lethal dose value
【参考】 TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 18,185,1971
【测试类型】 LD50 - Lethal dose, 50 percent kill
【接触途径】 Subcutaneous
【测试物种】 Rodent - rat
【剂量/时间】 5 gm/kg
【毒性作用】 Gastrointestinal - hypermotility, diarrhea
【参考】 TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 9,445,1966
【测试类型】 LD50 - Lethal dose, 50 percent kill
【接触途径】 Intravenous
【测试物种】 Rodent - rat
【剂量/时间】 171 mg/kg
【毒性作用】 Details of toxic effects not reported other than lethal dose value
【参考】 JCINAO Journal of Clinical Investigation. (Rockefeller Univ. Press, 1230 York Ave., New York, NY 10021) V.1- 1924- Volume(issue)/page/year: 28,943,1949
【测试类型】 LD50 - Lethal dose, 50 percent kill
【接触途径】 Oral
【测试物种】 Rodent - mouse
【剂量/时间】 1500 mg/kg
【毒性作用】 Details of toxic effects not reported other than lethal dose value
【参考】 ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 5,1,1955
【测试类型】 LD50 - Lethal dose, 50 percent kill
【接触途径】 Intraperitoneal
【测试物种】 Rodent - mouse
【剂量/时间】 1100 mg/kg
【毒性作用】 Details of toxic effects not reported other than lethal dose value
【参考】 DIPHAH Dissertationes Pharmaceuticae. (Warsaw, Poland) V.1-17, 1949-65. For publisher information, see PJPPAA. Volume(issue)/page/year: 14,21,1962
【测试类型】 LD50 - Lethal dose, 50 percent kill
【接触途径】 Subcutaneous
【测试物种】 Rodent - mouse
【剂量/时间】 400 mg/kg
【毒性作用】 Details of toxic effects not reported other than lethal dose value
【参考】 85ERAY "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978 Volume(issue)/page/year: 1,493,1978
【测试类型】 LD50 - Lethal dose, 50 percent kill
【接触途径】 Intravenous
【测试物种】 Rodent - mouse
【剂量/时间】 110 mg/kg
【毒性作用】 Behavioral - somnolence (general depressed activity) Behavioral - ataxia Lungs, Thorax, or Respiration - other changes
【参考】 JCINAO Journal of Clinical Investigation. (Rockefeller Univ. Press, 1230 York Ave., New York, NY 10021) V.1- 1924- Volume(issue)/page/year: 28,943,1949
【测试类型】 LD - Lethal dose
【接触途径】 Oral
【测试物种】 Mammal - dog
【剂量/时间】 >300 mg/kg
【毒性作用】 Details of toxic effects not reported other than lethal dose value
【参考】 JCINAO Journal of Clinical Investigation. (Rockefeller Univ. Press, 1230 York Ave., New York, NY 10021) V.1- 1924- Volume(issue)/page/year: 28,943,1949
【测试类型】 LDLo - Lowest published lethal dose
【接触途径】 Intravenous
【测试物种】 Mammal - dog
【剂量/时间】 150 mg/kg
【毒性作用】 Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - other changes
【参考】 JOBAAY Journal of Bacteriology. (American Soc. for Microbiology, 1913 I St., NW, Washington, DC 20006) V.1- 1916- Volume(issue)/page/year: 55,425,1948
【测试类型】 LD - Lethal dose
【接触途径】 Intramuscular
【测试物种】 Mammal - dog
【剂量/时间】 >101 mg/kg
【毒性作用】 Details of toxic effects not reported other than lethal dose value
【参考】 JCINAO Journal of Clinical Investigation. (Rockefeller Univ. Press, 1230 York Ave., New York, NY 10021) V.1- 1924- Volume(issue)/page/year: 28,943,1949
【测试类型】 LD50 - Lethal dose, 50 percent kill
【接触途径】 Intravenous
【测试物种】 Rodent - rabbit
【剂量/时间】 117 mg/kg
【毒性作用】 Details of toxic effects not reported other than lethal dose value
【参考】 JCINAO Journal of Clinical Investigation. (Rockefeller Univ. Press, 1230 York Ave., New York, NY 10021) V.1- 1924- Volume(issue)/page/year: 28,943,1949
【测试类型】 LD50 - Lethal dose, 50 percent kill
【接触途径】 Oral
【测试物种】 Rodent - guinea pig
【剂量/时间】 500 mg/kg
【毒性作用】 Details of toxic effects not reported other than lethal dose value
【参考】 FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 10,3,1955
【测试类型】 LD50 - Lethal dose, 50 percent kill
【接触途径】 Intravenous
【测试物种】 Rodent - guinea pig
【剂量/时间】 560 mg/kg
【毒性作用】 Details of toxic effects not reported other than lethal dose value
【参考】 FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 9,21,1954

〖其他多剂量毒性数据〗

【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Oral
【测试物种】 Rodent - rat
【剂量/时间】 60 mg/kg/60D-I
【毒性作用】 Nutritional and Gross Metabolic - weight loss or decreased weight gain
【参考】 GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 25(4),45,1981
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Oral
【测试物种】 Rodent - mouse
【剂量/时间】 17416 mg/kg/4W-I
【毒性作用】 Related to Chronic Data - death
【参考】 JCINAO Journal of Clinical Investigation. (Rockefeller Univ. Press, 1230 York Ave., New York, NY 10021) V.1- 1924- Volume(issue)/page/year: 28,943,1949
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Oral
【测试物种】 Rodent - mouse
【剂量/时间】 33600 mg/kg/14D-C
【毒性作用】 Liver - other changes Liver - changes in liver weight Nutritional and Gross Metabolic - weight loss or decreased weight gain
【参考】 TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 86,47,1996
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Intraperitoneal
【测试物种】 Rodent - mouse
【剂量/时间】 960 mg/kg/4D-I
【毒性作用】 Blood - changes in other cell count (unspecified) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases
【参考】 AMBIEH Antibiotiki i Meditsinskaya Biotekhnologiya. Antibiotics and Medical Biotechnology. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.30-V.32, 1985-1987 Volume(issue)/page/year: 30,449,1985
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Subcutaneous
【测试物种】 Rodent - mouse
【剂量/时间】 2800 mg/kg/2W-I
【毒性作用】 Behavioral - food intake (animal) Nutritional and Gross Metabolic - other changes Related to Chronic Data - death
【参考】 JCINAO Journal of Clinical Investigation. (Rockefeller Univ. Press, 1230 York Ave., New York, NY 10021) V.1- 1924- Volume(issue)/page/year: 28,943,1949
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Oral
【测试物种】 Mammal - dog
【剂量/时间】 6400 mg/kg/3W-I
【毒性作用】 Behavioral - food intake (animal) Kidney, Ureter, Bladder - proteinuria
【参考】 JCINAO Journal of Clinical Investigation. (Rockefeller Univ. Press, 1230 York Ave., New York, NY 10021) V.1- 1924- Volume(issue)/page/year: 28,943,1949
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Oral
【测试物种】 Rodent - guinea pig
【剂量/时间】 2100 mg/kg/2W-C
【毒性作用】 Nutritional and Gross Metabolic - other changes Related to Chronic Data - death
【参考】 JCINAO Journal of Clinical Investigation. (Rockefeller Univ. Press, 1230 York Ave., New York, NY 10021) V.1- 1924- Volume(issue)/page/year: 28,943,1949

〖致肿瘤数据数据〗

【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Oral
【测试物种】 Human - woman
【剂量/时间】 300 mg/kg/60W-I
【毒性作用】 Tumorigenic - Carcinogenic by RTECS criteria Blood - changes in bone marrow (not otherwise specified) Blood - leukemia
【参考】 NEJMAG New England Journal of Medicine. (Massachusetts Medical Soc., 10 Shattuck St., Boston, MA 02115) V.198- 1928- Volume(issue)/page/year: 277,1003,1967
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Intraperitoneal
【测试物种】 Rodent - mouse
【剂量/时间】 2500 mg/kg/5W-I
【毒性作用】 Tumorigenic - equivocal tumorigenic agent by RTECS criteria Blood - lymphoma, including Hodgkin's disease
【参考】 CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 41,3478,1981
【测试类型】 TD - Toxic dose (other than lowest)
【接触途径】 Oral
【测试物种】 Human - woman
【剂量/时间】 1680 mg/kg/6W-I
【毒性作用】 Tumorigenic - Carcinogenic by RTECS criteria Blood - aplastic anemia Blood - leukemia
【参考】 NEJMAG New England Journal of Medicine. (Massachusetts Medical Soc., 10 Shattuck St., Boston, MA 02115) V.198- 1928- Volume(issue)/page/year: 277,1003,1967
【测试类型】 TD - Toxic dose (other than lowest)
【接触途径】 Oral
【测试物种】 Human - man
【剂量/时间】 434 mg/kg/W-C
【毒性作用】 Tumorigenic - Carcinogenic by RTECS criteria Blood - aplastic anemia Blood - leukemia
【参考】 ACHAAH Acta Haematologica. (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.1- 1948- Volume(issue)/page/year: 66,267,1981

〖繁殖数据〗

【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Oral
【测试物种】 Rodent - ratDOSE : 23 gm/kgSEX/DURATION : female 1-21 day(s) after conception
【毒性作用】 Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - other effects to embryo Reproductive - Specific Developmental Abnormalities - homeostasis
【参考】 TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 12,291,1975
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Oral
【测试物种】 Rodent - ratDOSE : 2500 mg/kgSEX/DURATION : female 9 day(s) after conception
【毒性作用】 Reproductive - Specific Developmental Abnormalities - Central Nervous System
【参考】 AAGEAA Arkhiv Anatomii, Gistologii i Embriologii. Archives of Anatomy, Histology and Embryology. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-101, 1916-91. Discontinued Volume(issue)/page/year: 60(5),25,1971
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Oral
【测试物种】 Rodent - ratDOSE : 2500 mg/kgSEX/DURATION : female 11 day(s) after conception
【毒性作用】 Reproductive - Effects on Embryo or Fetus - fetal death
【参考】 AAGEAA Arkhiv Anatomii, Gistologii i Embriologii. Archives of Anatomy, Histology and Embryology. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-101, 1916-91. Discontinued Volume(issue)/page/year: 60(5),25,1971
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Oral
【测试物种】 Rodent - ratDOSE : 2 gm/kgSEX/DURATION : female 8 day(s) after conception
【毒性作用】 Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Specific Developmental Abnormalities - body wall
【参考】 TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 19,667,1971
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Intraperitoneal
【测试物种】 Rodent - ratDOSE : 250 mg/kgSEX/DURATION : female 3 day(s) after conception
【毒性作用】 Reproductive - Fertility - other measures of fertility
【参考】 EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945- Volume(issue)/page/year: 35,1649,1979
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Subcutaneous
【测试物种】 Rodent - ratDOSE : 2400 mg/kgSEX/DURATION : female 12-14 day(s) after conception
【毒性作用】 Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
【参考】 VHAGAS Verhandlungen der Anatomischen Gesellschaft. (VEB Gustav Fischer Verlag, Postfach 176, Jena, DDR-6900, Ger. Dem. Rep.) V.1- 1887- Volume(issue)/page/year: 71,623,1977
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Subcutaneous
【测试物种】 Rodent - ratDOSE : 3500 mg/kgSEX/DURATION : female 6-10 day(s) after conception
【毒性作用】 Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death
【参考】 OSDIAF Osaka Shiritsu Daigaku Igaku Zasshi. Journal of the Osaka City Medical Center. (Osaka, Japan) V.4-23, 1955-74. For publisher information, see OIGZDE. Volume(issue)/page/year: 14,107,1965
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Subcutaneous
【测试物种】 Rodent - ratDOSE : 3500 mg/kgSEX/DURATION : female 6-10 day(s) after conception
【毒性作用】 Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific Developmental Abnormalities - urogenital system
【参考】 OSDIAF Osaka Shiritsu Daigaku Igaku Zasshi. Journal of the Osaka City Medical Center. (Osaka, Japan) V.4-23, 1955-74. For publisher information, see OIGZDE. Volume(issue)/page/year: 14,107,1965
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Intravenous
【测试物种】 Rodent - ratDOSE : 2 gm/kgSEX/DURATION : female 10-14 day(s) after conception
【毒性作用】 Reproductive - Effects on Embryo or Fetus - cytological changes (including somatic cell genetic material) Reproductive - Effects on Embryo or Fetus - other effects to embryo
【参考】 AEMBAP Advances in Experimental Medicine and Biology. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.1- 1967- Volume(issue)/page/year: 27,291,1972
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Oral
【测试物种】 Rodent - mouseDOSE : 5500 mg/kgSEX/DURATION : female 5-15 day(s) after conception
【毒性作用】 Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
【参考】 TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 19,667,1971
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Oral
【测试物种】 Rodent - mouseDOSE : 7 gm/kgSEX/DURATION : female 6-12 day(s) after conception
【毒性作用】 Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
【参考】 TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 19,667,1971
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Oral
【测试物种】 Rodent - mouseDOSE : 6 gm/kgSEX/DURATION : female 8-10 day(s) after conception
【毒性作用】 Reproductive - Effects on Embryo or Fetus - fetal death
【参考】 TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 19,667,1971
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Oral
【测试物种】 Rodent - mouseDOSE : 175 mg/kgSEX/DURATION : female 15-21 day(s) after conception
【毒性作用】 Reproductive - Effects on Newborn - behavioral
【参考】 NEPHBW Neuropharmacology. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.9- 1970- Volume(issue)/page/year: 13,233,1974
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Parenteral
【测试物种】 Rodent - mouseDOSE : 2 gm/kgSEX/DURATION : female 12-14 day(s) after conception
【毒性作用】 Reproductive - Specific Developmental Abnormalities - Central Nervous System
【参考】 VHAGAS Verhandlungen der Anatomischen Gesellschaft. (VEB Gustav Fischer Verlag, Postfach 176, Jena, DDR-6900, Ger. Dem. Rep.) V.1- 1887- Volume(issue)/page/year: 67,551,1973
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Oral
【测试物种】 Rodent - rabbitDOSE : 4 gm/kgSEX/DURATION : female 8-11 day(s) after conception
【毒性作用】 Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death
【参考】 TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 19,667,1971
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Oral
【测试物种】 Rodent - rabbitDOSE : 4 gm/kgSEX/DURATION : female 6-9 day(s) after conception
【毒性作用】 Reproductive - Specific Developmental Abnormalities - musculoskeletal system
【参考】 TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 19,667,1971
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Parenteral
【测试物种】 Rodent - rabbitDOSE : 2700 mg/kgSEX/DURATION : female 11-19 day(s) after conception
【毒性作用】 Reproductive - Fertility - abortion Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death
【参考】 JJANAX Japanese Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan) V.21- 1968- Volume(issue)/page/year: 23,353,1970
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Parenteral
【测试物种】 Rodent - rabbitDOSE : 2700 mg/kgSEX/DURATION : female 2-10 day(s) after conception
【毒性作用】 Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)
【参考】 JJANAX Japanese Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan) V.21- 1968- Volume(issue)/page/year: 23,353,1970
〖致突变数据〗
【测试类型】 DNA damageTEST SYSTEM : Bacteria - Salmonella typhimurium
【剂量/时间】 5 mmol/L
【参考】 BBRCA9 Biochemical and Biophysical Research Communications. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 78,151,1977
【测试类型】 Mutation in microorganismsTEST SYSTEM : Bacteria - Escherichia coli
【剂量/时间】 5 mg/L
【参考】 NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 271,385,1978
【测试类型】 DNA repairTEST SYSTEM : Bacteria - Escherichia coli
【剂量/时间】 6 ug/disc
【参考】 MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 97,1,1982
【测试类型】 DNA damageTEST SYSTEM : Bacteria - Escherichia coli
【剂量/时间】 2 mmol/L
【参考】 BBRCA9 Biochemical and Biophysical Research Communications. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 78,151,1977
【测试类型】 Unscheduled DNA synthesisTEST SYSTEM : Bacteria - Escherichia coli
【剂量/时间】 8 mg/L
【参考】 JOBAAY Journal of Bacteriology. (American Soc. for Microbiology, 1913 I St., NW, Washington, DC 20006) V.1- 1916- Volume(issue)/page/year: 77,10,1959
【测试类型】 DNA inhibitionTEST SYSTEM : Bacteria - Escherichia coli
【剂量/时间】 2 gm/L
【参考】 JOBAAY Journal of Bacteriology. (American Soc. for Microbiology, 1913 I St., NW, Washington, DC 20006) V.1- 1916- Volume(issue)/page/year: 115,786,1973
【测试类型】 Phage inhibition capacityTEST SYSTEM : Bacteria - Escherichia coli
【剂量/时间】 1 gm/L
【参考】 ZAPOAK Zeitschrift fuer Allgemeine Mikrobiologie. (Akademie-Verlag GmbH, Postfach 1233, Berlin DDR-1086 Ger. Dem. Rep.) V.1- 1960- Volume(issue)/page/year: 12,583,1972
【测试类型】 Mutation test systems - not otherwise specifiedTEST SYSTEM : Bacteria - Bacillus subtilis
【剂量/时间】 10 mg/L
【参考】 MGGEAE Molecular and General Genetics. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.99- 1967- Volume(issue)/page/year: 189,73,1983
【测试类型】 Mutation in microorganismsTEST SYSTEM : Microorganism - not otherwise specified
【剂量/时间】 10 mg/L
【参考】 MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 74,113,1980
【测试类型】 Mutation in microorganismsTEST SYSTEM : Microorganism - not otherwise specified
【剂量/时间】 1200 mg/L
【参考】 ARMKA7 Archiv fuer Mikrobiologie. (Berlin, Fed. Rep. Ger.) V.1-94, 1930-73. For publisher information, see AMICCW. Volume(issue)/page/year: 81,1,1972
【测试类型】 Mutation in microorganismsTEST SYSTEM : Protozoa - Euglena gracilis
【剂量/时间】 3300 umol/L
【参考】 CYTZAM Cytobiologie. (Stuttgart, Fed. Rep. Ger.) V.1-18, 1969-79. For publisher information, see EJCBDN. Volume(issue)/page/year: 9,280,1974
【测试类型】 Cytogenetic analysis
【接触途径】 OralTEST SYSTEM : Insect - grasshopper
【剂量/时间】 5 mg
【参考】 PISCAD Proceedings of the Indian Science Congress. (Indian Science Congress Assoc., 14, Dr. Biresh Guha St., Calcutta, 700017, India) 1st- 1914- Volume(issue)/page/year: 54,408,1967
【测试类型】 Unscheduled DNA synthesisTEST SYSTEM : Human Liver
【剂量/时间】 1 mmol/L
【参考】 MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 260,65,1991
【测试类型】 DNA inhibitionTEST SYSTEM : Human Bone marrow
【剂量/时间】 1500 umo/L
【参考】 46GFA5 "Safety Problems Related to Chloramphenicol and Thiamphenicol Therapy," Najean, Y., et al., eds., New York, Raven Press, 1981 Volume(issue)/page/year: -,17,1981
【测试类型】 DNA inhibitionTEST SYSTEM : Human Lymphocyte
【剂量/时间】 1 mmol/L
【参考】 MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 320,207,1994
【测试类型】 Cytogenetic analysisTEST SYSTEM : Human Leukocyte
【剂量/时间】 100 mg/L
【参考】 CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 33,1829,1973
【测试类型】 Cytogenetic analysisTEST SYSTEM : Human Lymphocyte
【剂量/时间】 500 mg/L
【参考】 HUMAA7 Humangenetik. (Heidelberg, Fed. Rep. Ger.) V.1-30, 1964-75. For publisher information, see HUGEDQ. Volume(issue)/page/year: 7,305,1969
【测试类型】 DNA repairTEST SYSTEM : Rodent - rat Liver
【剂量/时间】 1600 umol/L
【参考】 CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1980- Volume(issue)/page/year: 10,543,1989
【测试类型】 DNA damageTEST SYSTEM : Rodent - rat Lung
【剂量/时间】 4 mmol/L
【参考】 MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 260,65,1991
【测试类型】 DNA damageTEST SYSTEM : Rodent - rat Liver
【剂量/时间】 2 mmol/L
【参考】 MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 260,65,1991
【测试类型】 Unscheduled DNA synthesisTEST SYSTEM : Rodent - rat Liver
【剂量/时间】 2 mmol/L
【参考】 MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 260,65,1991
【测试类型】 Body fluid assayTEST SYSTEM : Rodent - rat HeLa cell
【剂量/时间】 1 gm/kg
【参考】 MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 4,874,1967
【测试类型】 Cytogenetic analysis
【接触途径】 IntraperitonealTEST SYSTEM : Rodent - mouse
【剂量/时间】 500 mg/kg
【参考】 FOBLAN Folia Biologica (Prague). (Academic Press Inc. Ltd., 24-28 Oval Rd., London NW1 7DX, UK) V.1- 1955- Volume(issue)/page/year: 21,60,1975
【测试类型】 Cytogenetic analysis
【接触途径】 ParenteralTEST SYSTEM : Rodent - mouse
【剂量/时间】 50 mg/kg
【参考】 CHRTBC Chromosomes Today. (George Allen & Unwin Ltd., 40 Museum St., London WC1A 1LU, UK) V.1- 1966- Volume(issue)/page/year: 4,277,1973
【测试类型】 Sister chromatid exchangeTEST SYSTEM : Rodent - hamster Embryo
【剂量/时间】 30 mg/L
【参考】 SHIGAZ Shigaku. Ondotology. (Nippon Shika Daigaku Shigakkai, 1-9-20 Fujimi, Chiyodaku, Tokyo 102, Japan) V.38- 1949- Volume(issue)/page/year: 74,1385,1987
【测试类型】 Cytogenetic analysisTEST SYSTEM : Mammal - domestic Leukocyte
【剂量/时间】 500 ug/L
【参考】 RVMVAH Revue de Medecine Veterinaire (Toulouse). (Ecole Nationale Veterinaire de Toulouse, 23 Chemin des Capelles, 31076 Toulouse, France) V.89(2)- 1937- Volume(issue)/page/year: 126,1611,1975
【测试类型】 Cytogenetic analysisTEST SYSTEM : Mammal - pig Leukocyte
【剂量/时间】 50 ug/L
【参考】 RVMVAH Revue de Medecine Veterinaire (Toulouse). (Ecole Nationale Veterinaire de Toulouse, 23 Chemin des Capelles, 31076 Toulouse, France) V.89(2)- 1937- Volume(issue)/page/year: 126,1611,1975
【测试类型】 Sister chromatid exchangeTEST SYSTEM : Mammal - cattle Fibroblast
【剂量/时间】 5 mg/L
【参考】 RVTSA9 Research in Veterinary Science. (British Veterinary Assoc., 7 Mansfield St., London W1M OAT, UK) V.1- 1960- Volume(issue)/page/year: 52,256,1992
【测试类型】 Sister chromatid exchangeTEST SYSTEM : Mammal - cattle Lymphocyte
【剂量/时间】 5 mg/L
【参考】 MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 319,11,1993

◇◇◇综述◇◇◇

IARC Cancer Review:Human Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 10,85,1976 IARC Cancer Review:Human Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 50,169,1990 IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 10,85,1976 IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 50,169,1990 IARC Cancer Review:Group 2A IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 50,169,1990 TOXICOLOGY REVIEW PLMJAP Pahlavi Medical Journal. (Shiraz, Iran) V.1-9, 1970-78. Volume(issue)/page/year: 6,160,1975 TOXICOLOGY REVIEW CLANA4 Clinical Anesthesia. (Philadelphia, PA 19103) V.1-11, 1963-76. Volume(issue)/page/year: 10(Pt 1),283,1973 TOXICOLOGY REVIEW PCNAA8 Pediatric Clinics of North America. (W.B. Saunders Co., W. Washington Sq., Philadelphia, PA 19105) V.1- 1954- Volume(issue)/page/year: 8,413,1961

◇◇◇职业接触限量◇◇◇

OEL-RUSSIA:STEL 1 mg/m3 JAN 1993

◇◇◇NIOSH 标准发展和监测数据◇◇◇

【NIOSH 职业性接触鉴定数据】 NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84396 No. of Facilities: 165 (estimated) No. of Industries: 1 No. of Occupations: 6 No. of Employees: 11365 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84396 No. of Facilities: 2358 (estimated) No. of Industries: 3 No. of Occupations: 19 No. of Employees: 35571 (estimated) No. of Female Employees: 23544 (estimated)

◇◇◇在美国的情况◇◇◇

EPA GENETOX PROGRAM 1988, Positive: Rodent dominant lethal EPA GENETOX PROGRAM 1988, Negative: B subtilis rec assay; E coli polA without S9 EPA GENETOX PROGRAM 1988, Negative: E coli polA with S9; Histidine reversion-Ames test EPA GENETOX PROGRAM 1988, Negative: TRP reversion EPA GENETOX PROGRAM 1988, Inconclusive: Carcinogenicity-mouse/rat; B subtilis rec assay EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal EPA TSCA Section 8(b) CHEMICAL INVENTORY

◇◇◇全部数据完毕◇◇◇

益母草	菊花
百合花	西洋参

56-75-7