医康传媒

◇◇◇化学鉴别信息◇◇◇

【RTECS 编号】 AB9450000
【化学名】 Acetamide, N-fluoren-2-yl-
【CAS 登记号】 53-96-3
【BEILSTEIN 参考号】 2807677
【参考】 4-12-00-03373 (Beilstein Handbook Reference)
【上次更新时间】 199710
【引用数据项】 167
【分子式】 C15-H13-N-O
【分子量】 223.29
【维斯韦塞(氏)线的符号】 L B656 HHJ EMV1
【化合物描述】 Tumorigen Mutagen Reproductive Effector
【别名】 * AAF * 2-AAF * Acetamide, N-9H-fluoren-2-yl- * 2-Acetamidofluorene * 2-Acetaminofluorene * Acetoaminofluorene * 2-Acetylamino-fluoren * N-Acetyl-2-aminofluorene * 2-(Acetylamino)fluorene * 2-Acetylaminofluorene * Azetylaminofluoren * FAA * 2-FAA * 2-Fluorenylacetamide * N-2-Fluorenylacetamide * N-Fluoren-2-ylacetamide * N-9H-Fluoren-2-ylacetamide * RCRA waste number U005

◇◇◇卫生公害数据◇◇◇

〖急性毒性数据〗

【测试类型】 LDLo - Lowest published lethal dose
【接触途径】 Intraperitoneal
【测试物种】 Rodent - rat
【剂量/时间】 >200 mg/kg
【毒性作用】 Details of toxic effects not reported other than lethal dose value
【参考】 ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 56,151,1985
【测试类型】 LD50 - Lethal dose, 50 percent kill
【接触途径】 Oral
【测试物种】 Rodent - mouse
【剂量/时间】 810 mg/kg
【毒性作用】 Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - altered sleep time (including change in righting reflex) Kidney, Ureter, Bladder - other changes in urine composition
【参考】 PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 143,1117,1973
【测试类型】 LD50 - Lethal dose, 50 percent kill
【接触途径】 Intraperitoneal
【测试物种】 Rodent - mouse
【剂量/时间】 470 mg/kg
【毒性作用】 Details of toxic effects not reported other than lethal dose value
【参考】 MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 223,361,1989

〖致肿瘤数据数据〗

【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Oral
【测试物种】 Rodent - rat
【剂量/时间】 4368 mg/kg/2Y-C
【毒性作用】 Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Kidney, Ureter, Bladder - tumors
【参考】 JJCREP Japanese Journal of Cancer Research. (Elsevier Science Pub. BV, POB 211, 1000 AE Amsterdam, Netherlands) V.76- 1985- Volume(issue)/page/year: 84,237,1993
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Oral
【测试物种】 Rodent - rat
【剂量/时间】 672 mg/kg/8W-C
【毒性作用】 Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors
【参考】 TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 74,63,1984
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Administration onto the skin
【测试物种】 Rodent - rat
【剂量/时间】 260 mg/kg/71W-I
【毒性作用】 Tumorigenic - Carcinogenic by RTECS criteria Endocrine - adrenal cortex tumors Skin and Appendages - tumors
【参考】 JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8. Volume(issue)/page/year: 10,1201,1950
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Intraperitoneal
【测试物种】 Rodent - rat
【剂量/时间】 192 mg/kg/4W-I
【毒性作用】 Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Skin and Appendages - tumors
【参考】 CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 32,1554,1972
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Subcutaneous
【测试物种】 Rodent - rat
【剂量/时间】 2600 mg/kg/43W-I
【毒性作用】 Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors
【参考】 JJCREP Japanese Journal of Cancer Research. (Elsevier Science Pub. BV, POB 211, 1000 AE Amsterdam, Netherlands) V.76- 1985- Volume(issue)/page/year: 85,794,1994
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Parenteral
【测试物种】 Rodent - rat
【剂量/时间】 1700 mg/kg/17W-I
【毒性作用】 Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors Skin and Appendages - tumors
【参考】 CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 6,617,1946
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Implant
【测试物种】 Rodent - rat
【剂量/时间】 22 mg/kg
【毒性作用】 Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors Tumorigenic - tumors at site of application
【参考】 CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 33,2489,1973
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Oral
【测试物种】 Rodent - mouse
【剂量/时间】 2738 mg/kg/2.5Y-C
【毒性作用】 Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Kidney, Ureter, Bladder - tumors
【参考】 JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76- Volume(issue)/page/year: 33,327,1991
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Oral
【测试物种】 Rodent - mouse
【剂量/时间】 7840 mg/kg/49W-C
【毒性作用】 Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Kidney, Ureter, Bladder - tumors
【参考】 EJCAAH European Journal of Cancer. (Oxford, UK) V.1-17(6), 1965-1981. For publisher information, see EJCODS. Volume(issue)/page/year: 5,41,1969
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Intraperitoneal
【测试物种】 Rodent - mouse
【剂量/时间】 60 mg/kg/2W-I
【毒性作用】 Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors
【参考】 TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 82,19,1986
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Subcutaneous
【测试物种】 Rodent - mouse
【剂量/时间】 400 mg/kg female 15 day(s) after conception
【毒性作用】 Tumorigenic - equivocal tumorigenic agent by RTECS criteria Reproductive - Tumorigenic effects - transplacental tumorigenesis Liver - tumors
【参考】 IJCNAW International Journal of Cancer. (International Union Against Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland) V.1- 1966- Volume(issue)/page/year: 20,293,1977
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Implant
【测试物种】 Rodent - mouse
【剂量/时间】 96 mg/kg
【毒性作用】 Tumorigenic - equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder - tumors
【参考】 GMCRDC Gann Monograph on Cancer Research. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No. 11- 1971- Volume(issue)/page/year: 17,383,1975
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Oral
【测试物种】 Mammal - dog
【剂量/时间】 2625 mg/kg/25W-C
【毒性作用】 Tumorigenic - neoplastic by RTECS criteria Liver - tumors
【参考】 CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 10,266,1950
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Oral
【测试物种】 Mammal - cat
【剂量/时间】 11 gm/kg/69W-C
【毒性作用】 Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors
【参考】 CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 11,280,1951
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Oral
【测试物种】 Rodent - rabbit
【剂量/时间】 6500 mg/kg/65W-I
【毒性作用】 Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - tumors Kidney, Ureter, Bladder - Kidney tumors
【参考】 PAMIAD Pathologica et Microbiologia. (Basel, Switzerland) V.23-43, 1960-75. For publisher information, see ECEBDI. Volume(issue)/page/year: 32,177,1968
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Intraperitoneal
【测试物种】 Rodent - rabbit
【剂量/时间】 3600 mg/kg/40W-I
【毒性作用】 Tumorigenic - equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder - tumors
【参考】 CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 27,838,1967
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Oral
【测试物种】 Rodent - hamster
【剂量/时间】 9240 mg/kg/44W-C
【毒性作用】 Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors
【参考】 GANNA2 Gann. Japanese Journal of Cancer Research. (Tokyo, Japan) V.1-75, 1907-84. For publisher information, see JJCREP. Volume(issue)/page/year: 59,239,1968
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Intratracheal
【测试物种】 Rodent - hamster
【剂量/时间】 8800 mg/kg/73W-I
【毒性作用】 Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - tumors
【参考】 JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8. Volume(issue)/page/year: 50,503,1973
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Multiple routes
【测试物种】 Rodent - hamster
【剂量/时间】 3370 mg/kg/37W-I
【毒性作用】 Tumorigenic - equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder - tumors
【参考】 INURAQ Investigative Urology. (Baltimore, MD) V.1-19, 1963-81. For publisher information, see JOURAA. Volume(issue)/page/year: 14,206,1976
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Oral
【测试物种】 Bird - chicken
【剂量/时间】 2800 mg/kg/13W-I
【毒性作用】 Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors Liver - tumors
【参考】 BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947- Volume(issue)/page/year: 9,163,1955
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Parenteral
【测试物种】 Bird - chicken
【剂量/时间】 3430 mg/kg/3Y
【毒性作用】 Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Kidney, Ureter, Bladder - Kidney tumors
【参考】 BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947- Volume(issue)/page/year: 8,147,1954
【测试类型】 TD - Toxic dose (other than lowest)
【接触途径】 Administration onto the skin
【测试物种】 Rodent - rat
【剂量/时间】 2590 mg/kg/23W-I
【毒性作用】 Tumorigenic - Carcinogenic by RTECS criteria Sense Organs and Special Senses (Ear) - effect, not otherwise specified Liver - tumors
【参考】 CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 28,234,1968
【测试类型】 TD - Toxic dose (other than lowest)
【接触途径】 Oral
【测试物种】 Rodent - rat
【剂量/时间】 2100 mg/kg/25W-C
【毒性作用】 Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors
【参考】 CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year: 19,55,1983
【测试类型】 TD - Toxic dose (other than lowest)
【接触途径】 Oral
【测试物种】 Rodent - rat
【剂量/时间】 1220 mg/kg/19W-C
【毒性作用】 Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Skin and Appendages - tumors
【参考】 CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 22,1002,1962
【测试类型】 TD - Toxic dose (other than lowest)
【接触途径】 Oral
【测试物种】 Rodent - rat
【剂量/时间】 2100 mg/kg/30W-C
【毒性作用】 Tumorigenic - Carcinogenic by RTECS criteria Skin and Appendages - tumors
【参考】 TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 5,526,1963
【测试类型】 TD - Toxic dose (other than lowest)
【接触途径】 Oral
【测试物种】 Rodent - rat
【剂量/时间】 2610 mg/kg/23W-C
【毒性作用】 Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Skin and Appendages - tumors
【参考】 JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8. Volume(issue)/page/year: 10,1201,1950
【测试类型】 TD - Toxic dose (other than lowest)
【接触途径】 Oral
【测试物种】 Rodent - mouse
【剂量/时间】 13 gm/kg/53W-C
【毒性作用】 Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Kidney, Ureter, Bladder - tumors
【参考】 JCPCBR Journal of Clinical Pharmacology. (Hall Assoc., PO Box 482, Stamford, CT 06904) V.13- 1973- Volume(issue)/page/year: 19,591,1979
【测试类型】 TD - Toxic dose (other than lowest)
【接触途径】 Oral
【测试物种】 Rodent - rat
【剂量/时间】 1344 mg/kg/16W-C
【毒性作用】 Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Liver - hepatitis, fibrous (cirrhosis, post-necrotic scarring)
【参考】 TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 19,687,1971
【测试类型】 TD - Toxic dose (other than lowest)
【接触途径】 Oral
【测试物种】 Rodent - rat
【剂量/时间】 2940 mg/kg/35W-C
【毒性作用】 Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Nutritional and Gross Metabolic - weight loss or decreased weight gain
【参考】 TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 19,687,1971
【测试类型】 TD - Toxic dose (other than lowest)
【接触途径】 Oral
【测试物种】 Rodent - rabbit
【剂量/时间】 14 gm/kg/56W-I
【毒性作用】 Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - tumors Reproductive - Tumorigenic effects - ovarian tumors
【参考】 CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 27,838,1967
【测试类型】 TD - Toxic dose (other than lowest)
【接触途径】 Oral
【测试物种】 Rodent - mouse
【剂量/时间】 13140 mg/kg/1Y-C
【毒性作用】 Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Skin and Appendages - tumors
【参考】 TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 41,535,1977

〖繁殖数据〗

【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Oral
【测试物种】 Rodent - ratDOSE : 300 mg/kgSEX/DURATION : female 9 day(s) after conception
【毒性作用】 Reproductive - Specific Developmental Abnormalities - Central Nervous System
【参考】 IARCCD IARC Scientific Publications. (Geneva, Switzerland) No.1-26, 1971-78. For publisher information, see IAPUDO. Volume(issue)/page/year: 4,112,1973
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Intraperitoneal
【测试物种】 Rodent - mouseDOSE : 100 mg/kgSEX/DURATION : female 10 day(s) after conception
【毒性作用】 Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
【参考】 KAIZAN Kaibogaku Zasshi. Journal of Anatomy. (Nippon Kaibo Gakkai, c/o Tokyo Daigaku Igakubu, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113, Japan) V.1- 1928- Volume(issue)/page/year: 37,239,1962
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Intraperitoneal
【测试物种】 Rodent - mouseDOSE : 100 mg/kgSEX/DURATION : female 8 day(s) after conception
【毒性作用】 Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
【参考】 KAIZAN Kaibogaku Zasshi. Journal of Anatomy. (Nippon Kaibo Gakkai, c/o Tokyo Daigaku Igakubu, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113, Japan) V.1- 1928- Volume(issue)/page/year: 37,239,1962
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Intraperitoneal
【测试物种】 Rodent - mouseDOSE : 625 mg/kgSEX/DURATION : male 5 day(s) pre-mating
【毒性作用】 Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)
【参考】 MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 124,235,1983
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Intraperitoneal
【测试物种】 Rodent - mouseDOSE : 2500 mg/kgSEX/DURATION : male 5 day(s) pre-mating
【毒性作用】 Reproductive - Paternal Effects - testes, epididymis, sperm duct
【参考】 MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 124,235,1983
〖致突变数据〗
【测试类型】 Mutation in microorganismsTEST SYSTEM : Bacteria - Salmonella typhimurium
【剂量/时间】 100 ug/plate
【参考】 CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year: 22,297,1978
【测试类型】 Mutation in microorganismsTEST SYSTEM : Bacteria - Salmonella typhimurium
【剂量/时间】 300 ng/plate
【参考】 ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 6(Suppl 2),1,1984
【测试类型】 Mutation test systems - not otherwise specifiedTEST SYSTEM : Bacteria - Salmonella typhimurium
【剂量/时间】 50 mg/L
【参考】 MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 192,239,1987
【测试类型】 Unscheduled DNA synthesisTEST SYSTEM : Bacteria - Salmonella typhimurium
【剂量/时间】 1 ug
【参考】 ECEBDI Experimental Cell Biology. (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.44- 1976- Volume(issue)/page/year: 50,271,1982
【测试类型】 Mutation test systems - not otherwise specifiedTEST SYSTEM : Bacteria - Escherichia coli
【剂量/时间】 100 umol/L
【参考】 MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 203,81,1988
【测试类型】 Mutation in microorganismsTEST SYSTEM : Bacteria - Escherichia coli
【剂量/时间】 100 ug/plate
【参考】 PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1981- Volume(issue)/page/year: 1,387,1981
【测试类型】 DNA repairTEST SYSTEM : Bacteria - Escherichia coli
【剂量/时间】 10 mg/L
【参考】 JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ. Volume(issue)/page/year: 62,873,1979
【测试类型】 DNA adductTEST SYSTEM : Bacteria - Escherichia coli
【剂量/时间】 5 umol/L
【参考】 MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 89,95,1981
【测试类型】 Phage inhibition capacityTEST SYSTEM : Bacteria - Escherichia coli
【剂量/时间】 200 mg/L
【参考】 PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1981- Volume(issue)/page/year: 1,224,1981
【测试类型】 DNA damageTEST SYSTEM : Bacteria - Bacillus subtilis
【剂量/时间】 1 mg/disc
【参考】 PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1981- Volume(issue)/page/year: 1,175,1981
【测试类型】 Mutation in microorganismsTEST SYSTEM : Microorganism - not otherwise specified
【剂量/时间】 200 ug/plate
【参考】 CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year: 22,297,1978
【测试类型】 Specific locus test
【接触途径】 ParenteralTEST SYSTEM : Insect - Drosophila melanogaster
【剂量/时间】 20 mmol/L
【参考】 IJCNAW International Journal of Cancer. (International Union Against Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland) V.1- 1966- Volume(issue)/page/year: 9,284,1972
【测试类型】 DNA repair
【接触途径】 OralTEST SYSTEM : Insect - Drosophila melanogaster
【剂量/时间】 500 mg/L
【参考】 MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 290,175,1993
【测试类型】 Mutation in microorganismsTEST SYSTEM : Yeast - Saccharomyces cerevisiae
【剂量/时间】 100 mg/L
【参考】 CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 33,1576,1985
【测试类型】 Gene conversion and mitotic recombinationTEST SYSTEM : Yeast - Saccharomyces cerevisiae
【剂量/时间】 1 gm/L
【参考】 PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1981- Volume(issue)/page/year: 1,434,1981
【测试类型】 Sex chromosome loss and nondisjunctionTEST SYSTEM : Yeast - Saccharomyces cerevisiae
【剂量/时间】 50 mg/L
【参考】 PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1981- Volume(issue)/page/year: 1,468,1981
【测试类型】 Mutation in microorganismsTEST SYSTEM : Yeast - Schizosaccharomyces pombe
【剂量/时间】 100 ug/L
【参考】 PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1981- Volume(issue)/page/year: 1,424,1981
【测试类型】 DNA repairTEST SYSTEM : Yeast - Schizosaccharomyces pombe
【剂量/时间】 2800 nmol/L
【参考】 CNJGA8 Canadian Journal of Genetics and Cytology. (National Research Council of Canada, Publication Sales and Distribution, Ottawa ON K1A OR6, Canada) V.1- 1959- Volume(issue)/page/year: 24,771,1982
【测试类型】 Sex chromosome loss and nondisjunction
【接触途径】 ParenteralTEST SYSTEM : Insect - silkworm
【剂量/时间】 500 ug
【参考】 KIKNAJ Kokuritsu Idengaku Kenkyusho Nenpo. Annual Report of the National Institute of Genetics. (Kokuritsu Idengaku Kenkyusho, 1111 Yata, Mishima, Shizuoka-ken 411, Japan) No. 1- 1949- Volume(issue)/page/year: (28),71,1977
【测试类型】 Specific locus test
【接触途径】 OralTEST SYSTEM : Insect - not otherwise specified
【剂量/时间】 1000 ppm
【参考】 MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 268,155,1992
【测试类型】 DNA adductTEST SYSTEM : Human HeLa cell
【剂量/时间】 5 umol/L
【参考】 MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 89,95,1981
【测试类型】 DNA adductTEST SYSTEM : Human Cells - not otherwise specified
【剂量/时间】 1200 nmol/L
【参考】 PAACA3 Proceedings of the American Association for Cancer Research. (Waverly Press, 428 E. Preston St., Baltimore, MD 21202) V.1- 1954- Volume(issue)/page/year: 24,63,1983
【测试类型】 DNA damageTEST SYSTEM : Human Fibroblast
【剂量/时间】 1 mmol/L
【参考】 ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 7,267,1985
【测试类型】 Unscheduled DNA synthesisTEST SYSTEM : Human Fibroblast
【剂量/时间】 100 umol/L/5H
【参考】 IJCNAW International Journal of Cancer. (International Union Against Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland) V.1- 1966- Volume(issue)/page/year: 16,284,1975
【测试类型】 Unscheduled DNA synthesisTEST SYSTEM : Human HeLa cell
【剂量/时间】 10 umol/L
【参考】 CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 38,2621,1978
【测试类型】 Unscheduled DNA synthesisTEST SYSTEM : Human Liver
【剂量/时间】 1 umol/L
【参考】 BANRDU Banbury Report. (Cold Spring Harbor Laboratory, POB 100, Cold Spring Harbor, NY 11724) V.1- 1979- Volume(issue)/page/year: 13,101,1982
【测试类型】 Sister chromatid exchangeTEST SYSTEM : Human Lymphocyte
【剂量/时间】 4400 ug/L
【参考】 CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 40,4775,1980
【测试类型】 Mutation in mammalian somatic cellsTEST SYSTEM : Human Lymphocyte
【剂量/时间】 25 umol/L
【参考】 ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 4,304,1982
【测试类型】 Micronucleus test
【接触途径】 OralTEST SYSTEM : Rodent - rat
【剂量/时间】 50 mg/kg
【参考】 MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 251,59,1991
【测试类型】 DNA repairTEST SYSTEM : Rodent - rat Liver
【剂量/时间】 1 umol/L
【参考】 JJCREP Japanese Journal of Cancer Research. (Elsevier Science Pub. BV, POB 211, 1000 AE Amsterdam, Netherlands) V.76- 1985- Volume(issue)/page/year: 79,204,1988
【测试类型】 Morphological transformation
【接触途径】 IntraperitonealTEST SYSTEM : Rodent - rat
【剂量/时间】 200 mg/kg
【参考】 CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 10,435,1989
【测试类型】 Morphological transformation
【接触途径】 OralTEST SYSTEM : Rodent - rat
【剂量/时间】 480 mg/kg/8W (Intermittent)
【参考】 CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 5,171,1984
【测试类型】 Morphological transformationTEST SYSTEM : Rodent - rat Embryo
【剂量/时间】 100 ug/L
【参考】 JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ. Volume(issue)/page/year: 67,1303,1981
【测试类型】 Morphological transformationTEST SYSTEM : Rodent - rat Liver
【剂量/时间】 100 umol/L
【参考】 CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 43,5087,1983
【测试类型】 DNA damageTEST SYSTEM : Rodent - rat Liver
【剂量/时间】 3 umol/L
【参考】 SinJF# Personal Communication from J.F. Sina, Merck Institute for Therapeutic Research, West Point, PA 19486, Oct. 26, 1982 Volume(issue)/page/year: 26OCT1982
【测试类型】 DNA adduct
【接触途径】 IntraperitonealTEST SYSTEM : Rodent - rat
【剂量/时间】 18 umol/kg
【参考】 CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year: 48,15,1984
【测试类型】 DNA adduct
【接触途径】 OralTEST SYSTEM : Rodent - rat
【剂量/时间】 70 mg/kg
【参考】 CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 15,857,1994
【测试类型】 DNA damageTEST SYSTEM : Rodent - rat Liver
【剂量/时间】 2000 ppm
【参考】 ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 4,667,1982
【测试类型】 Unscheduled DNA synthesisTEST SYSTEM : Rodent - rat Liver
【剂量/时间】 2 ug/L
【参考】 MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 190,159,1987
【测试类型】 Unscheduled DNA synthesis
【接触途径】 OralTEST SYSTEM : Rodent - rat
【剂量/时间】 5 mg/kg
【参考】 MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 150,383,1985
【测试类型】 DNA damageTEST SYSTEM : Rodent - rat Liver
【剂量/时间】 50 ug/L
【参考】 ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 6,427,1984
【测试类型】 Unscheduled DNA synthesisTEST SYSTEM : Rodent - rat Cells - not otherwise specified
【剂量/时间】 3200 umol/L
【参考】 SHKKAN Shika Kiso Igakkai Zasshi. Journal of the Japanese Association for Basic Dentistry. (Shika Kiso Igakkai, Hanayama Bldg., 1-44-2 Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1959- Volume(issue)/page/year: 22,300,1980
【测试类型】 Unscheduled DNA synthesisTEST SYSTEM : Rodent - rat Sperm
【剂量/时间】 100 umol/L
【参考】 ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 6,273,1984
【测试类型】 Unscheduled DNA synthesis
【接触途径】 IntraperitonealTEST SYSTEM : Rodent - rat
【剂量/时间】 10 mg/kg
【参考】 CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year: 22,211,1984
【测试类型】 DNA inhibitionTEST SYSTEM : Rodent - rat Liver
【剂量/时间】 100 nmol/L
【参考】 CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 45,337,1985
【测试类型】 DNA inhibition
【接触途径】 OralTEST SYSTEM : Rodent - rat
【剂量/时间】 420 mg/kg/6W
【参考】 CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 33,397,1973
【测试类型】 Mutation test systems - not otherwise specified
【接触途径】 OralTEST SYSTEM : Rodent - rat
【剂量/时间】 72 mg/kg/3D (Continuous)
【参考】 EXMPA6 Experimental and Molecular Pathology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1962- Volume(issue)/page/year: 31,333,1979
【测试类型】 Mutation test systems - not otherwise specified
【接触途径】 OralTEST SYSTEM : Rodent - rat
【剂量/时间】 420 mg/kg/6W
【参考】 CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 33,397,1973
【测试类型】 Body fluid assayTEST SYSTEM : Rodent - rat Bacteria - Salmonella typhimurium
【剂量/时间】 1600 ug/kg
【参考】 PNASA6 Proceedings of the National Academy of Sciences of the United States of America. (National Academy of Sciences, Printing & Pub. Office, 2101 Constitution Ave., Washington, DC 20418) V.1- 1915- Volume(issue)/page/year: 71,737,1974
【测试类型】 Body fluid assayTEST SYSTEM : Rodent - rat Ovary
【剂量/时间】 53 mg/kg
【参考】 MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 143,263,1985
【测试类型】 Cytogenetic analysis
【接触途径】 OralTEST SYSTEM : Rodent - rat
【剂量/时间】 50 mg/kg
【参考】 MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 251,59,1991
【测试类型】 Cytogenetic analysisTEST SYSTEM : Rodent - rat Liver
【剂量/时间】 10 mg/L
【参考】 MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 64,329,1979
【测试类型】 Sister chromatid exchange
【接触途径】 IntraperitonealTEST SYSTEM : Rodent - rat
【剂量/时间】 100 mg/kg
【参考】 MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 91,363,1981
【测试类型】 Sister chromatid exchange
【接触途径】 Administration onto the skinTEST SYSTEM : Rodent - rat
【剂量/时间】 100 mg/kg
【参考】 MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 91,363,1981
【测试类型】 Sister chromatid exchangeTEST SYSTEM : Rodent - rat Liver
【剂量/时间】 4500 umol/L
【参考】 MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 93,409,1982
【测试类型】 Sister chromatid exchangeTEST SYSTEM : Rodent - rat Cells - not otherwise specified
【剂量/时间】 400 umol/L
【参考】 MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 93,409,1982
【测试类型】 Sister chromatid exchange
【接触途径】 OralTEST SYSTEM : Rodent - rat
【剂量/时间】 25 mg/kg
【参考】 MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 251,59,1991
【测试类型】 Sex chromosome loss and nondisjunction
【接触途径】 OralTEST SYSTEM : Rodent - rat
【剂量/时间】 50 mg/kg
【参考】 CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 17,1051,1996
【测试类型】 Mutation in mammalian somatic cellsTEST SYSTEM : Rodent - rat Liver
【剂量/时间】 1 umol/L
【参考】 MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 130,53,1984
【测试类型】 Host-mediated assayTEST SYSTEM : Rodent - rat Bacteria - Salmonella typhimurium
【剂量/时间】 90 mg/kg/5D
【参考】 AJCNAC American Journal of Clinical Nutrition. (American Soc. for Clinical Nutrition, Inc., 9650 Rockville Pike, Bethesda, MD 20814) V.2- 1954- Volume(issue)/page/year: 30,1921,1977
【测试类型】 Micronucleus test
【接触途径】 IntraperitonealTEST SYSTEM : Rodent - mouse
【剂量/时间】 2 mg/kg
【参考】 PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1981- Volume(issue)/page/year: 1,686,1981
【测试类型】 Micronucleus test
【接触途径】 OralTEST SYSTEM : Rodent - mouse
【剂量/时间】 75 mg/kg
【参考】 MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 223,361,1989
【测试类型】 Mutation in microorganismsTEST SYSTEM : Rodent - mouse Lymphocyte
【剂量/时间】 40 mg/L
【参考】 ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 7(Suppl 3),10,1985
【测试类型】 Specific locus test
【接触途径】 IntraperitonealTEST SYSTEM : Rodent - mouse
【剂量/时间】 223 mg/kg
【参考】 MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 117,201,1983
【测试类型】 Morphological transformationTEST SYSTEM : Rodent - mouse Mammary gland
【剂量/时间】 1 ug/L
【参考】 CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 39,1784,1979
【测试类型】 DNA adductTEST SYSTEM : Rodent - mouse Liver
【剂量/时间】 60 umol/L
【参考】 JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ. Volume(issue)/page/year: 62,947,1979
【测试类型】 DNA adductTEST SYSTEM : Rodent - mouse Ascites tumor
【剂量/时间】 5 umol/L
【参考】 MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 89,95,1981
【测试类型】 Unscheduled DNA synthesisTEST SYSTEM : Rodent - mouse Liver
【剂量/时间】 10 umol/L
【参考】 ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 5,1,1983
【测试类型】 DNA inhibition
【接触途径】 OralTEST SYSTEM : Rodent - mouse
【剂量/时间】 160 mg/kg
【参考】 CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year: 5,153,1972
【测试类型】 DNA inhibition
【接触途径】 IntraperitonealTEST SYSTEM : Rodent - mouse
【剂量/时间】 200 mg/kg
【参考】 MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 46,305,1977
【测试类型】 Mutation test systems - not otherwise specified
【接触途径】 OralTEST SYSTEM : Rodent - mouse
【剂量/时间】 160 mg/kg
【参考】 CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year: 5,153,1972
【测试类型】 Body fluid assayTEST SYSTEM : Rodent - mouse Bacteria - Salmonella typhimurium
【剂量/时间】 20 mg/kg
【参考】 MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 117,79,1983
【测试类型】 Sister chromatid exchange
【接触途径】 IntraperitonealTEST SYSTEM : Rodent - mouse
【剂量/时间】 20 mg/kg
【参考】 MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 157,181,1985
【测试类型】 Mutation in mammalian somatic cellsTEST SYSTEM : Rodent - mouse Lymphocyte
【剂量/时间】 15 mg/L
【参考】 MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 125,291,1984
【测试类型】 Host-mediated assayTEST SYSTEM : Rodent - mouse Bacteria - Salmonella typhimurium
【剂量/时间】 495 mg/kg
【参考】 JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ. Volume(issue)/page/year: 62,911,1979
【测试类型】 Sperm Morphology
【接触途径】 IntraperitonealTEST SYSTEM : Rodent - mouse
【剂量/时间】 625 mg/kg/5D (Continuous)
【参考】 MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 124,235,1983
【测试类型】 Micronucleus test
【接触途径】 IntraperitonealTEST SYSTEM : Rodent - hamster
【剂量/时间】 2 gm/kg
【参考】 MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 43,255,1977
【测试类型】 Micronucleus testTEST SYSTEM : Rodent - hamster Embryo
【剂量/时间】 1 umol/L
【参考】 MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 203,397,1988
【测试类型】 Mutation in microorganismsTEST SYSTEM : Rodent - hamster Ovary
【剂量/时间】 20 mg/L
【参考】 MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 112,329,1983
【测试类型】 Morphological transformation
【接触途径】 IntraperitonealTEST SYSTEM : Rodent - hamster
【剂量/时间】 750 mg/kg
【参考】 ARPAAQ Archives of Pathology. (Chicago, IL) V.5(3)-50(3), 1928-50; V.70-99, 1960-75. For publisher information, see APLMAS. Volume(issue)/page/year: 95,380,1973
【测试类型】 Morphological transformationTEST SYSTEM : Rodent - hamster Kidney
【剂量/时间】 80 ug/L
【参考】 BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947- Volume(issue)/page/year: 37,873,1978
【测试类型】 Morphological transformationTEST SYSTEM : Rodent - hamster Embryo
【剂量/时间】 12500 ug/L
【参考】 JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ. Volume(issue)/page/year: 67,1303,1981
【测试类型】 DNA damageTEST SYSTEM : Rodent - hamster Lung
【剂量/时间】 300 umol/L/2H
【参考】 BBRCA9 Biochemical and Biophysical Research Communications. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 72,732,1976
【测试类型】 Unscheduled DNA synthesisTEST SYSTEM : Rodent - hamster Liver
【剂量/时间】 10 nmol/L
【参考】 ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 6,1,1984
【测试类型】 Cytogenetic analysisTEST SYSTEM : Rodent - hamster Lung
【剂量/时间】 10 mg/L
【参考】 ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.1- 1978- Volume(issue)/page/year: 4,41,1980
【测试类型】 Sister chromatid exchange
【接触途径】 IntraperitonealTEST SYSTEM : Rodent - hamster
【剂量/时间】 50 mg/kg
【参考】 MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 113,33,1983
【测试类型】 Sister chromatid exchangeTEST SYSTEM : Rodent - hamster Ovary
【剂量/时间】 100 umol/L/150M
【参考】 MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 58,103,1978
【测试类型】 Sister chromatid exchange
【接触途径】 OralTEST SYSTEM : Rodent - hamster
【剂量/时间】 50 mg/kg
【参考】 MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 113,33,1983
【测试类型】 Sister chromatid exchangeTEST SYSTEM : Rodent - hamster Liver
【剂量/时间】 6 mg/L
【参考】 MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 207,69,1988
【测试类型】 Sex chromosome loss and nondisjunctionTEST SYSTEM : Rodent - hamster Liver
【剂量/时间】 100 mg/L
【参考】 PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1981- Volume(issue)/page/year: 5,397,1985
【测试类型】 Mutation in microorganismsTEST SYSTEM : Rodent - mouse Lymphocyte
【剂量/时间】 12300 ug/L
【参考】 EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 12(Suppl 13),37,1988
【测试类型】 DNA adductTEST SYSTEM : Bird - wild bird species Lymphocyte
【剂量/时间】 700 pmol/plate
【参考】 CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 37,3756,1977
【测试类型】 Unscheduled DNA synthesisTEST SYSTEM : Rodent - rabbit Cells - not otherwise specified
【剂量/时间】 10 umol/L
【参考】 CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 8,401,1987
【测试类型】 Sister chromatid exchange
【接触途径】 IntraperitonealTEST SYSTEM : Rodent - rabbit
【剂量/时间】 3 mg/kg
【参考】 MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 58,321,1978
【测试类型】 Sister chromatid exchange
【接触途径】 ParenteralTEST SYSTEM : Bird - chicken
【剂量/时间】 3125 ng/kg
【参考】 ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 2,435,1980

◇◇◇综述◇◇◇

TOXICOLOGY REVIEW 32XPAD "Teratology," Berry, C.L., and D.E. Poswillo, eds., New York, Springer, 1975 Volume(issue)/page/year: -,49,1975 TOXICOLOGY REVIEW 85CVA2 "Oncology 1970, Proceedings of the Tenth International Cancer Congress," Chicago, Year Book Medical Pub., 1971 Volume(issue)/page/year: 5,63,1970 TOXICOLOGY REVIEW ZEKBAI Zeitschrift fuer Krebsforschung. (Berlin, Fed. Rep. Ger.) V.1-75, 1903-71. For publisher information, see JCROD7. Volume(issue)/page/year: 71,32,1968 TOXICOLOGY REVIEW ADCSAJ Advances in Chemistry Series. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) No.1- 1950- Volume(issue)/page/year: 13,271,1970 TOXICOLOGY REVIEW BLFSBY Basic Life Sciences. (Plenum Pub. Corp., 223 Spring St., New York, NY 10003) V.1- 1973- Volume(issue)/page/year: 24,129,1983

◇◇◇美国标准和规章◇◇◇

MSHA STANDARD:air-SUSPECTED CARCINOGEN DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8. Volume(issue)/page/year: 3,8,1973 OSHA PEL (Gen Indu):see CFR 29,1910.1014 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):see CFR 29,1926.1114 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):see CFR 29,1915.1014 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA-cancer suspect agent CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1014,1987

◇◇◇职业接触限量◇◇◇

OEL-BELGIUM;Carcinogen JAN 1993 OEL-FINLAND;Carcinogen JAN 1993 OEL-SWEDEN;Carcinogen JAN 1993

◇◇◇NIOSH 标准发展和监测数据◇◇◇

【参考】 NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992
【NIOSH 职业性接触鉴定数据】 NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6612 No. of Facilities: 75 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 373 (estimated)

◇◇◇在美国的情况◇◇◇

EPA GENETOX PROGRAM 1988, Positive: Body fluid assay; Carcinogenicity-mouse/rat EPA GENETOX PROGRAM 1988, Positive: Host-mediated assay; L5178Y cells in vitro-TK test EPA GENETOX PROGRAM 1988, Positive: Mammalian micronucleus; E coli polA with S9 EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test; In vitro SCE-nonhuman EPA GENETOX PROGRAM 1988, Positive: In vitro UDS in rat liver EPA GENETOX PROGRAM 1988, Positive/dose response: Cell transform.-BALB/c-3T3; SHE-clonal assay EPA GENETOX PROGRAM 1988, Negative: Cell transform.-SA7/SHE; E coli polA without S9 EPA GENETOX PROGRAM 1988, Negative: In vitro SCE-human lymphocytes; In vitro SCE-human EPA GENETOX PROGRAM 1988, Negative: Sperm morphology-mouse; V79 cell culture-gene mutation EPA GENETOX PROGRAM 1988, Negative: S cerevisiae gene conversion; S cerevisiae-homozygosis EPA GENETOX PROGRAM 1988, Inconclusive: Cell transform.-RLV F344 rat embryo EPA GENETOX PROGRAM 1988, Inconclusive: In vivo SCE-nonhuman; D melanogaster Sex-linked lethal EPA GENETOX PROGRAM 1988, Inconclusive: In vitro UDS-human fibroblast EPA GENETOX PROGRAM 1988, Positive: CHO gene mutation EPA TSCA Section 8(b) CHEMICAL INVENTORY EPA TSCA Section 8(d) unpublished health/safety studies EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998 NTP 7th Annual Report on Carcinogens, 1992 : anticipated to be carcinogen

◇◇◇全部数据完毕◇◇◇

益母草	菊花
百合花	西洋参

53-96-3