73-31-4

更新日期：2018-11-23 浏览次数：141

摘要：73-31-4, RTECS NUMBER : AC5955000 CHEMICAL NAME : Acetamide, N-(2-(5-methoxyindol-3-yl)ethyl)- CAS R

◇◇◇化学鉴别信息◇◇◇

【RTECS 编号】 AC5955000
【化学名】 Acetamide, N-(2-(5-methoxyindol-3-yl)ethyl)-
【CAS 登记号】 73-31-4
【BEILSTEIN 参考号】 0205542
【参考】 5-22-12-00042 (Beilstein Handbook Reference)
【上次更新时间】 199806
【引用数据项】 39
【分子式】 C13-H16-N2-O2
【分子量】 232.31
【维斯韦塞(氏)线的符号】 T56 BMJ D2MV1 GO1
【化合物描述】 Tumorigen Drug Mutagen Reproductive Effector Hormone
【别名】 * Acetamide, N-(2-(5-methoxy-1H-indol-3-yl)ethyl)- * N-Acetyl-5-methoxytryptamine * Melatonin * Melatonine * 5-Methoxy-N-acetyltryptamine * N-(2-(5-Methoxy-1H-indol-3-yl)ethyl)acetamide

◇◇◇卫生公害数据◇◇◇

〖急性毒性数据〗

【测试类型】 LD50 - Lethal dose, 50 percent kill
【接触途径】 Intraperitoneal
【测试物种】 Rodent - mouse
【剂量/时间】 1375 mg/kg
【毒性作用】 Details of toxic effects not reported other than lethal dose value
【参考】 PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 17,559,1983
【测试类型】 LD50 - Lethal dose, 50 percent kill
【接触途径】 Intravenous
【测试物种】 Rodent - mouse
【剂量/时间】 180 mg/kg
【毒性作用】 Details of toxic effects not reported other than lethal dose value
【参考】 CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#02739

〖其他多剂量毒性数据〗

【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Subcutaneous
【测试物种】 Rodent - mouse
【剂量/时间】 15 mg/kg/2W-I
【毒性作用】 Blood - pigmented or nucleated red blood cells Blood - changes in erythrocyte (RBC) count Blood - changes in leukocyte (WBC) count
【参考】 IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- Volume(issue)/page/year: 34,19758,1996

〖致肿瘤数据数据〗

【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Subcutaneous
【测试物种】 Rodent - mouse
【剂量/时间】 4200 mg/kg/20W-I
【毒性作用】 Tumorigenic - Carcinogenic by RTECS criteria Blood - leukemia Blood - lymphoma, including Hodgkin's disease
【参考】 GETRE8 Gematologiya i Transfuziologiya. Hematology and Transfusion Science. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.28- 1983- Volume(issue)/page/year: 28(2),47,1983

〖繁殖数据〗

【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Oral
【测试物种】 Rodent - ratDOSE : 27 mg/kgSEX/DURATION : female 1 day(s) pre-mating
【毒性作用】 Reproductive - Fertility - other measures of fertility
【参考】 JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 22,63,1979
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Intraperitoneal
【测试物种】 Rodent - ratDOSE : 2800 ug/kgSEX/DURATION : female 28 day(s) pre-mating
【毒性作用】 Reproductive - Maternal Effects - menstrual cycle changes or disorders
【参考】 ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21203) V.1- 1917- Volume(issue)/page/year: 75,238,1964
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Intraperitoneal
【测试物种】 Rodent - ratDOSE : 140 ug/kgSEX/DURATION : female 28 day(s) pre-mating
【毒性作用】 Reproductive - Maternal Effects - ovaries, fallopian tubes
【参考】 SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year: 141,277,1963
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Intraperitoneal
【测试物种】 Rodent - ratDOSE : 7500 ug/kgSEX/DURATION : female 1 day(s) pre-mating
【毒性作用】 Reproductive - Fertility - other measures of fertility
【参考】 CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 4,385,1971
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Subcutaneous
【测试物种】 Rodent - ratDOSE : 900 mg/kgSEX/DURATION : male 30 day(s) pre-mating
【毒性作用】 Reproductive - Fertility - mating performance (e.g. # sperm positive females per # females mated; # copulations per # estrus cycles) Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
【参考】 TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 31(Suppl),68,1986
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Subcutaneous
【测试物种】 Rodent - ratDOSE : 1400 ug/kgSEX/DURATION : female 28 day(s) pre-mating
【毒性作用】 Reproductive - Maternal Effects - menstrual cycle changes or disorders
【参考】 ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21203) V.1- 1917- Volume(issue)/page/year: 75,238,1964
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Subcutaneous
【测试物种】 Rodent - ratDOSE : 140 ug/kgSEX/DURATION : female 28 day(s) pre-mating
【毒性作用】 Reproductive - Maternal Effects - ovaries, fallopian tubes
【参考】 ANYAA9 Annals of the New York Academy of Sciences. (New York Academy of Sciences, 2 E. 63rd St., New York, NY 10021) V.1- 1877- Volume(issue)/page/year: 117,228,1964
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Subcutaneous
【测试物种】 Rodent - ratDOSE : 80 ug/kgSEX/DURATION : male 20 day(s) pre-mating
【毒性作用】 Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands
【参考】 BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309 W. Clark St., Champaign, IL 61820) V.1- 1969- Volume(issue)/page/year: 33,618,1985
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Subcutaneous
【测试物种】 Rodent - ratDOSE : 500 ug/kgSEX/DURATION : female 1 day(s) pre-mating
【毒性作用】 Reproductive - Fertility - other measures of fertility
【参考】 NUNDAJ Neuroendocrinology. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.1- 1965/66- Volume(issue)/page/year: 12,354,1973
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Intravenous
【测试物种】 Rodent - ratDOSE : 500 ug/kgSEX/DURATION : female 1 day(s) pre-mating
【毒性作用】 Reproductive - Fertility - other measures of fertility
【参考】 NUNDAJ Neuroendocrinology. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.1- 1965/66- Volume(issue)/page/year: 12,354,1973
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Ocular
【测试物种】 Rodent - ratDOSE : 375 ug/kgSEX/DURATION : female 1 day(s) pre-mating
【毒性作用】 Reproductive - Fertility - other measures of fertility
【参考】 NUNDAJ Neuroendocrinology. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.1- 1965/66- Volume(issue)/page/year: 12,354,1973
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Ocular
【测试物种】 Rodent - ratDOSE : 50 ug/kgSEX/DURATION : female 1 day(s) pre-mating
【毒性作用】 Reproductive - Maternal Effects - ovaries, fallopian tubes
【参考】 NUNDAJ Neuroendocrinology. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.1- 1965/66- Volume(issue)/page/year: 12,354,1973
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Parenteral
【测试物种】 Rodent - ratDOSE : 36 mg/kgSEX/DURATION : male 30 day(s) pre-mating
【毒性作用】 Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands
【参考】 JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 21,363,1970
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Intraperitoneal
【测试物种】 Rodent - mouseDOSE : 4 mg/kgSEX/DURATION : female 19 day(s) pre-mating
【毒性作用】 Reproductive - Maternal Effects - menstrual cycle changes or disorders
【参考】 INJFA3 International Journal of Fertility. (Allen Press, 1041 New Hampshire, St., Lawrence, KS 66044) V.1- 1955- Volume(issue)/page/year: 21,65,1976
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Subcutaneous
【测试物种】 Rodent - mouseDOSE : 560 mg/kgSEX/DURATION : female 70 day(s) after conception
【毒性作用】 Reproductive - Maternal Effects - other effects Reproductive - Specific Developmental Abnormalities - endocrine system
【参考】 JPRSE9 Journal of Pineal Research. (Munksgaard International Publishers, POB 2148, DK-1016, Copenhagen K, Denmark) V.1- 1984- Volume(issue)/page/year: 13,13,1992
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Parenteral
【测试物种】 Rodent - mouseDOSE : 14 mg/kgSEX/DURATION : male 70 day(s) pre-mating
【毒性作用】 Reproductive - Paternal Effects - testes, epididymis, sperm duct
【参考】 BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309 W. Clark St., Champaign, IL 61820) V.1- 1969- Volume(issue)/page/year: 23,1069,1980
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Parenteral
【测试物种】 Rodent - mouseDOSE : 70 mg/kgSEX/DURATION : male 70 day(s) pre-mating
【毒性作用】 Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands
【参考】 BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309 W. Clark St., Champaign, IL 61820) V.1- 1969- Volume(issue)/page/year: 23,1069,1980
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Unreported
【测试物种】 Rodent - mouseDOSE : 5600 ug/kgSEX/DURATION : female 14 day(s) pre-mating
【毒性作用】 Reproductive - Maternal Effects - menstrual cycle changes or disorders
【参考】 ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21203) V.1- 1917- Volume(issue)/page/year: 75,238,1964
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Subcutaneous
【测试物种】 Rodent - rabbitDOSE : 7500 ug/kgSEX/DURATION : female 1 day(s) pre-mating
【毒性作用】 Reproductive - Fertility - other measures of fertility
【参考】 ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21203) V.1- 1917- Volume(issue)/page/year: 83,599,1968
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Subcutaneous
【测试物种】 Rodent - hamsterDOSE : 12 mg/kgSEX/DURATION : male 60 day(s) pre-mating
【毒性作用】 Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands Reproductive - Paternal Effects - other effects on male
【参考】 HRMRA3 Hormone Research. (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.4- 1978- Volume(issue)/page/year: 15,99,1981
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Subcutaneous
【测试物种】 Rodent - hamsterDOSE : 1260 ug/kgSEX/DURATION : female 9 week(s) pre-mating
【毒性作用】 Reproductive - Maternal Effects - ovaries, fallopian tubes Reproductive - Maternal Effects - uterus, cervix, vagina
【参考】 JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 78,381,1986
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Subcutaneous
【测试物种】 Rodent - hamsterDOSE : 9800 ug/kgSEX/DURATION : female 49 day(s) pre-mating
【毒性作用】 Reproductive - Maternal Effects - menstrual cycle changes or disorders
【参考】 NUNDAJ Neuroendocrinology. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.1- 1965/66- Volume(issue)/page/year: 33,112,1981
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Subcutaneous
【测试物种】 Rodent - hamsterDOSE : 7 mg/kgSEX/DURATION : male 35 day(s) pre-mating
【毒性作用】 Reproductive - Paternal Effects - testes, epididymis, sperm duct
【参考】 BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309 W. Clark St., Champaign, IL 61820) V.1- 1969- Volume(issue)/page/year: 22,277,1980
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Parenteral
【测试物种】 Rodent - hamsterDOSE : 21 mg/kgSEX/DURATION : male 15 week(s) pre-mating
【毒性作用】 Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands
【参考】 PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 175,254,1984
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Parenteral
【测试物种】 Rodent - hamsterDOSE : 14 mg/kgSEX/DURATION : female 10 week(s) pre-mating
【毒性作用】 Reproductive - Maternal Effects - uterus, cervix, vagina Reproductive - Maternal Effects - other effects
【参考】 BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309 W. Clark St., Champaign, IL 61820) V.1- 1969- Volume(issue)/page/year: 36,719,1987
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Implant
【测试物种】 Rodent - hamsterDOSE : 12480 ug/kgSEX/DURATION : male 60 day(s) pre-mating
【毒性作用】 Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands
【参考】 SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year: 190,280,1975
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Implant
【测试物种】 Rodent - hamsterDOSE : 4032 ug/kgSEX/DURATION : male 42 day(s) pre-mating
【毒性作用】 Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)
【参考】 PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 151,502,1976
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Oral
【测试物种】 Mammal - domesticDOSE : 1700 ug/kgSEX/DURATION : female 51 day(s) pre-mating
【毒性作用】 Reproductive - Maternal Effects - menstrual cycle changes or disorders
【参考】 JANSAG Journal of Animal Science. (American Soc. of Animal Science, 309 W. Clark St., Champaign, IL 61820) V.1- 1942- Volume(issue)/page/year: 66,459,1988
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Oral
【测试物种】 Mammal - domesticDOSE : 1429 ug/kgSEX/DURATION : female 30 day(s) pre-mating
【毒性作用】 Reproductive - Maternal Effects - menstrual cycle changes or disorders Reproductive - Maternal Effects - other effects
【参考】 JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 95,709,1992
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Subcutaneous
【测试物种】 Mammal - domesticDOSE : 1200 ug/kgSEX/DURATION : female 40 day(s) pre-mating
【毒性作用】 Reproductive - Maternal Effects - menstrual cycle changes or disorders
【参考】 JANSAG Journal of Animal Science. (American Soc. of Animal Science, 309 W. Clark St., Champaign, IL 61820) V.1- 1942- Volume(issue)/page/year: 66,1855,1988
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Implant
【测试物种】 Mammal - domesticDOSE : 16 mg/kgSEX/DURATION : female 17 week(s) after conception
【毒性作用】 Reproductive - Specific Developmental Abnormalities - endocrine system
【参考】 ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21203) V.1- 1917- Volume(issue)/page/year: 125,400,1989
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Intravaginal
【测试物种】 Mammal - domesticDOSE : 4600 ug/kgSEX/DURATION : female 1 day(s) pre-mating
【毒性作用】 Reproductive - Maternal Effects - other effects
【参考】 JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 74,287,1985
〖致突变数据〗
【测试类型】 Mutation test systems - not otherwise specifiedTEST SYSTEM : Human Lymphocyte
【剂量/时间】 200 umol/L
【参考】 MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 351,187,1996
【测试类型】 Mutation test systems - not otherwise specified
【接触途径】 SubcutaneousTEST SYSTEM : Rodent - rat
【剂量/时间】 7 mg/kg/8W (Intermittent)
【参考】 CYTBAI Cytobios. (Faculty Press, 88 Regent St., Cambridge, UK) V.1- 1969- Volume(issue)/page/year: 65,115,1991

◇◇◇在美国的情况◇◇◇

NTP Carcinogenesis studies; selected, October 1997

◇◇◇全部数据完毕◇◇◇

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