医康传媒

◇◇◇化学鉴别信息◇◇◇

【RTECS 编号】 VT9625000
【化学名】 Serine, diazoacetate (ester)
【CAS 登记号】 115-02-6
【上次更新时间】 199709
【引用数据项】 83
【分子式】 C5-H7-N3-O4
【分子量】 173.15
【维斯韦塞(氏)线的符号】 QVYZ1OV1UNN
【化合物描述】 Tumorigen Drug Mutagen Reproductive Effector Natural Product
【别名】 * Acetic acid, diazo-, ester with serine * Azaserin * Azaserine * L-Azaserine * AZS * CI-337 * CL 337 * CN-15,757 * Diazoacetate (ester) L-serine * L-Diazoacetate (ester) serine * O-Diazoacetyl-L-serine * NSC-742 * P-165 * L-Serine, diazoacetate * Serine, diazoacetate (ester), L- * L-Serine diazoacetate (ester) * RCRA waste number U015

◇◇◇卫生公害数据◇◇◇

〖急性毒性数据〗

【测试类型】 LD50 - Lethal dose, 50 percent kill
【接触途径】 Oral
【测试物种】 Rodent - rat
【剂量/时间】 170 mg/kg
【毒性作用】 Nutritional and Gross Metabolic - weight loss or decreased weight gain
【参考】 CANCAR Cancer (Philadelphia). (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1948- Volume(issue)/page/year: 10,889,1957
【测试类型】 LD50 - Lethal dose, 50 percent kill
【接触途径】 Intraperitoneal
【测试物种】 Rodent - rat
【剂量/时间】 70 mg/kg
【毒性作用】 Details of toxic effects not reported other than lethal dose value
【参考】 PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 94,27,1957
【测试类型】 LD50 - Lethal dose, 50 percent kill
【接触途径】 Intracerebral
【测试物种】 Rodent - rat
【剂量/时间】 >400 ug/kg
【毒性作用】 Details of toxic effects not reported other than lethal dose value
【参考】 JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949- Volume(issue)/page/year: 18,760,1966
【测试类型】 LD50 - Lethal dose, 50 percent kill
【接触途径】 Oral
【测试物种】 Rodent - mouse
【剂量/时间】 150 mg/kg
【毒性作用】 Behavioral - somnolence (general depressed activity) Nutritional and Gross Metabolic - weight loss or decreased weight gain
【参考】 CANCAR Cancer (Philadelphia). (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1948- Volume(issue)/page/year: 10,889,1957
【测试类型】 LD50 - Lethal dose, 50 percent kill
【接触途径】 Intraperitoneal
【测试物种】 Rodent - mouse
【剂量/时间】 100 mg/kg
【毒性作用】 Behavioral - somnolence (general depressed activity) Nutritional and Gross Metabolic - weight loss or decreased weight gain
【参考】 CANCAR Cancer (Philadelphia). (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1948- Volume(issue)/page/year: 10,889,1957
【测试类型】 LD50 - Lethal dose, 50 percent kill
【接触途径】 Subcutaneous
【测试物种】 Rodent - mouse
【剂量/时间】 50 mg/kg
【毒性作用】 Details of toxic effects not reported other than lethal dose value
【参考】 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 4(1),432,1980
【测试类型】 LD50 - Lethal dose, 50 percent kill
【接触途径】 Intravenous
【测试物种】 Rodent - mouse
【剂量/时间】 62 mg/kg
【毒性作用】 Details of toxic effects not reported other than lethal dose value
【参考】 85ERAY "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978 Volume(issue)/page/year: 2,1249,1978
【测试类型】 LDLo - Lowest published lethal dose
【接触途径】 Intravenous
【测试物种】 Mammal - dog
【剂量/时间】 30 mg/kg
【毒性作用】 Gastrointestinal - changes in structure or function of salivary glands Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Blood - changes in bone marrow (not otherwise specified)
【参考】 TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 22,595,1972

〖其他多剂量毒性数据〗

【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Intraperitoneal
【测试物种】 Rodent - mouse
【剂量/时间】 155 mg/kg/10D-I
【毒性作用】 Related to Chronic Data - death
【参考】 JAJAAA Journal of Antibiotics, Series A. (Tokyo, Japan) V.6-20, 1953-67. For publisher information, see JANTAJ. Volume(issue)/page/year: 8,120,1955

〖致肿瘤数据数据〗

【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Oral
【测试物种】 Rodent - rat
【剂量/时间】 150 mg/kg/5W-C
【毒性作用】 Tumorigenic - neoplastic by RTECS criteria Gastrointestinal - tumors Kidney, Ureter, Bladder - tumors
【参考】 CANCAR Cancer (Philadelphia). (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1948- Volume(issue)/page/year: 47,1562,1981
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Intraperitoneal
【测试物种】 Rodent - rat
【剂量/时间】 30 mg/kg
【毒性作用】 Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors Tumorigenic - tumors at site of application
【参考】 CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 10,311,1989
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Intraperitoneal
【测试物种】 Rodent - rat
【剂量/时间】 30 mg/kg
【毒性作用】 Tumorigenic - Carcinogenic by RTECS criteria Tumorigenic - tumors at site of application
【参考】 CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 8,1831,1987
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Oral
【测试物种】 Rodent - mouse
【剂量/时间】 150 mg/kg/8W-I
【毒性作用】 Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors
【参考】 TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 82,19,1986
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Intraperitoneal
【测试物种】 Rodent - mouse
【剂量/时间】 30 mg/kg/8W-I
【毒性作用】 Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors
【参考】 TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 82,19,1986
【测试类型】 TD - Toxic dose (other than lowest)
【接触途径】 Intraperitoneal
【测试物种】 Rodent - rat
【剂量/时间】 120 mg/kg/24W-I
【毒性作用】 Tumorigenic - neoplastic by RTECS criteria Gastrointestinal - tumors Kidney, Ureter, Bladder - Kidney tumors
【参考】 CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year: 4,229,1978
【测试类型】 TD - Toxic dose (other than lowest)
【接触途径】 Intraperitoneal
【测试物种】 Rodent - rat
【剂量/时间】 150 mg/kg/5W-I
【毒性作用】 Tumorigenic - neoplastic by RTECS criteria Gastrointestinal - tumors
【参考】 JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ. Volume(issue)/page/year: 62,1269,1979
【测试类型】 TD - Toxic dose (other than lowest)
【接触途径】 Intraperitoneal
【测试物种】 Rodent - rat
【剂量/时间】 440 mg/kg/13W-I
【毒性作用】 Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors
【参考】 CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 40,592,1980
【测试类型】 TD - Toxic dose (other than lowest)
【接触途径】 Intraperitoneal
【测试物种】 Rodent - rat
【剂量/时间】 50 mg/kg
【毒性作用】 Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - changes in structure or function of endocrine pancreas Gastrointestinal - colon tumors
【参考】 CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year: 9,43,1980
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Intraperitoneal
【测试物种】 Rodent - rat
【剂量/时间】 120 mg/kg/24W-I
【毒性作用】 Tumorigenic - neoplastic by RTECS criteria Gastrointestinal - tumors
【参考】 GANNA2 Gann. Japanese Journal of Cancer Research. (Tokyo, Japan) V.1-75, 1907-84. For publisher information, see JJCREP. Volume(issue)/page/year: 69,633,1978
【测试类型】 TD - Toxic dose (other than lowest)
【接触途径】 Intraperitoneal
【测试物种】 Rodent - rat
【剂量/时间】 60 mg/kg/6W-I
【毒性作用】 Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors
【参考】 PAACA3 Proceedings of the American Association for Cancer Research. (Waverly Press, 428 E. Preston St., Baltimore, MD 21202) V.1- 1954- Volume(issue)/page/year: 21,109,1980
【测试类型】 TD - Toxic dose (other than lowest)
【接触途径】 Intraperitoneal
【测试物种】 Rodent - rat
【剂量/时间】 210 mg/kg/6W-I
【毒性作用】 Tumorigenic - neoplastic by RTECS criteria Gastrointestinal - tumors Kidney, Ureter, Bladder - tumors
【参考】 CANCAR Cancer (Philadelphia). (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1948- Volume(issue)/page/year: 47,1562,1981
【测试类型】 TD - Toxic dose (other than lowest)
【接触途径】 Intraperitoneal
【测试物种】 Rodent - rat
【剂量/时间】 30 mg/kg/6W-I
【毒性作用】 Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors
【参考】 FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. Volume(issue)/page/year: 34,827,1975
【测试类型】 TD - Toxic dose (other than lowest)
【接触途径】 Intraperitoneal
【测试物种】 Rodent - rat
【剂量/时间】 150 mg/kg/15W-I
【毒性作用】 Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors
【参考】 AJPAA4 American Journal of Pathology. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1925- Volume(issue)/page/year: 105,94,1981
【测试类型】 TD - Toxic dose (other than lowest)
【接触途径】 Intraperitoneal
【测试物种】 Rodent - rat
【剂量/时间】 260 mg/kg/26W-I
【毒性作用】 Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors Kidney, Ureter, Bladder - Kidney tumors
【参考】 CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 35,2249,1975

〖繁殖数据〗

【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Oral
【测试物种】 Rodent - ratDOSE : 2500 ug/kgSEX/DURATION : female 8 day(s) after conception
【毒性作用】 Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
【参考】 PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 94,27,1957
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Oral
【测试物种】 Rodent - ratDOSE : 2500 ug/kgSEX/DURATION : female 8 day(s) after conception
【毒性作用】 Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - homeostasis
【参考】 PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 94,27,1957
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Intraperitoneal
【测试物种】 Rodent - ratDOSE : 2500 ug/kgSEX/DURATION : female 10 day(s) after conception
【毒性作用】 Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
【参考】 CANCAR Cancer (Philadelphia). (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1948- Volume(issue)/page/year: 9,955,1956
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Intraperitoneal
【测试物种】 Rodent - ratDOSE : 7500 ug/kgSEX/DURATION : female 9-11 day(s) after conception
【毒性作用】 Reproductive - Effects on Embryo or Fetus - fetal death
【参考】 CANCAR Cancer (Philadelphia). (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1948- Volume(issue)/page/year: 9,955,1956
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Intraperitoneal
【测试物种】 Rodent - ratDOSE : 500 ug/kgSEX/DURATION : female 11 day(s) after conception
【毒性作用】 Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
【参考】 CANCAR Cancer (Philadelphia). (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1948- Volume(issue)/page/year: 9,955,1956
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Intraperitoneal
【测试物种】 Rodent - ratDOSE : 10 mg/kgSEX/DURATION : female 7-8 day(s) after conception
【毒性作用】 Reproductive - Fertility - abortion
【参考】 PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 94,27,1957
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Intramuscular
【测试物种】 Mammal - dogDOSE : 15 mg/kgSEX/DURATION : female 20-22 day(s) after conception
【毒性作用】 Reproductive - Fertility - other measures of fertility
【参考】 JAVMA4 Journal of the American Veterinary Medical Association. (American Veterinary Medical Assoc., 930 N. Meacham Rd., Schaumburg, IL 60196) V.48- 1915- Volume(issue)/page/year: 130,159,1957
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Intravenous
【测试物种】 Rodent - rabbitDOSE : 20 mg/kgSEX/DURATION : female 16-17 day(s) after conception
【毒性作用】 Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord)
【参考】 ARGYAJ Archiv fuer Gynaekologie. (Munich, Fed. Rep. Ger.) V.1-225, 1870-1978. For publisher information, see ARCGDG. Volume(issue)/page/year: 194,346,1961
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Intraperitoneal
【测试物种】 Rodent - hamsterDOSE : 2 mg/kgSEX/DURATION : female 8 day(s) after conception
【毒性作用】 Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Specific Developmental Abnormalities - musculoskeletal system
【参考】 EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945- Volume(issue)/page/year: 39,324,1983
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Intraperitoneal
【测试物种】 Rodent - hamsterDOSE : 2500 ug/kgSEX/DURATION : female 8 day(s) after conception
【毒性作用】 Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
【参考】 EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945- Volume(issue)/page/year: 39,324,1983
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Intravenous
【测试物种】 Rodent - hamsterDOSE : 2 mg/kgSEX/DURATION : female 8 day(s) after conception
【毒性作用】 Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Specific Developmental Abnormalities - musculoskeletal system
【参考】 EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945- Volume(issue)/page/year: 39,324,1983
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Intravenous
【测试物种】 Rodent - hamsterDOSE : 2500 ug/kgSEX/DURATION : female 8 day(s) after conception
【毒性作用】 Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
【参考】 EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945- Volume(issue)/page/year: 39,324,1983
〖致突变数据〗
【测试类型】 Mutation in microorganismsTEST SYSTEM : Bacteria - Salmonella typhimurium
【剂量/时间】 200 ng/plate
【参考】 PNASA6 Proceedings of the National Academy of Sciences of the United States of America. (National Academy of Sciences, Printing & Pub. Office, 2101 Constitution Ave., Washington, DC 20418) V.1- 1915- Volume(issue)/page/year: 72,5135,1975
【测试类型】 Mutation in microorganismsTEST SYSTEM : Bacteria - Escherichia coli
【剂量/时间】 100 ug/disc
【参考】 APMBAY Applied Microbiology. (Washington, DC) V.1-30, 1953-75. For publisher information, see AEMIDF. Volume(issue)/page/year: 6,23,1958
【测试类型】 Mutation test systems - not otherwise specifiedTEST SYSTEM : Bacteria - Escherichia coli
【剂量/时间】 600 pmol/tube
【参考】 MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 147,79,1985
【测试类型】 DNA repairTEST SYSTEM : Bacteria - Escherichia coli
【剂量/时间】 50 ug/plate
【参考】 CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 34,1658,1974
【测试类型】 DNA damageTEST SYSTEM : Bacteria - Escherichia coli
【剂量/时间】 20 mg/L
【参考】 MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 94,31,1982
【测试类型】 Mutation test systems - not otherwise specifiedTEST SYSTEM : Bacteria - Escherichia coli
【剂量/时间】 100 mmol/L
【参考】 RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970- Volume(issue)/page/year: 2,271,1971
【测试类型】 Phage inhibition capacityTEST SYSTEM : Bacteria - Escherichia coli
【剂量/时间】 10 ug/L
【参考】 APMBAY Applied Microbiology. (Washington, DC) V.1-30, 1953-75. For publisher information, see AEMIDF. Volume(issue)/page/year: 12,234,1964
【测试类型】 Mutation in microorganismsTEST SYSTEM : Bacteria - Bacillus subtilis
【剂量/时间】 500 umol/L
【参考】 EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945- Volume(issue)/page/year: 39,530,1983
【测试类型】 Mutation in microorganismsTEST SYSTEM : Microorganism - not otherwise specified
【剂量/时间】 1 mg/plate
【参考】 JGAMA9 Journal of General and Applied Microbiology. (Microbiology Research Foundation, c/o Japan Academic Soc. Center Bldg., 2-4-16 Yayoi, Bunkyo-ku, Tokyo, 113, Japan) V.1- 1955- Volume(issue)/page/year: 11,129,1965
【测试类型】 DNA damageTEST SYSTEM : Human Fibroblast
【剂量/时间】 10 mmol/L
【参考】 ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 7,267,1985
【测试类型】 Morphological transformationTEST SYSTEM : Rodent - rat Cells - not otherwise specified
【剂量/时间】 300 umol/L
【参考】 CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 14,1027,1993
【测试类型】 Morphological transformation
【接触途径】 ParenteralTEST SYSTEM : Rodent - rat
【剂量/时间】 20 mg/kg
【参考】 CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year: 7,265,1979
【测试类型】 Morphological transformation
【接触途径】 IntraperitonealTEST SYSTEM : Rodent - rat
【剂量/时间】 30 mg/kg
【参考】 CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 8,1831,1987
【测试类型】 DNA damage
【接触途径】 SubcutaneousTEST SYSTEM : Rodent - rat
【剂量/时间】 10 mg/kg
【参考】 CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 9,1007,1988
【测试类型】 DNA damageTEST SYSTEM : Rodent - rat Liver
【剂量/时间】 30 umol/L
【参考】 MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 113,357,1983
【测试类型】 DNA damage
【接触途径】 IntraperitonealTEST SYSTEM : Rodent - rat
【剂量/时间】 3 mg/kg
【参考】 CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 8,1033,1987
【测试类型】 DNA damage
【接触途径】 OralTEST SYSTEM : Rodent - rat
【剂量/时间】 100 mg/kg
【参考】 ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 4,667,1982
【测试类型】 DNA adduct
【接触途径】 ParenteralTEST SYSTEM : Rodent - rat
【剂量/时间】 3 mg/kg
【参考】 CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year: 16,65,1982
【测试类型】 DNA damageTEST SYSTEM : Rodent - rat Cells - not otherwise specified
【剂量/时间】 2 mg/L
【参考】 CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 8,1033,1987
【测试类型】 Unscheduled DNA synthesis
【接触途径】 OralTEST SYSTEM : Rodent - rat
【剂量/时间】 100 mg/kg
【参考】 ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 4,553,1982
【测试类型】 Unscheduled DNA synthesisTEST SYSTEM : Rodent - rat Liver
【剂量/时间】 25 umol/L
【参考】 MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 315,147,1994
【测试类型】 Unscheduled DNA synthesisTEST SYSTEM : Rodent - rat Cells - not otherwise specified
【剂量/时间】 30 mg/L
【参考】 JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ. Volume(issue)/page/year: 71,523,1983
【测试类型】 Unscheduled DNA synthesis
【接触途径】 UnreportedTEST SYSTEM : Rodent - rat
【剂量/时间】 100 mg/kg
【参考】 ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 6,446,1984
【测试类型】 DNA inhibition
【接触途径】 ParenteralTEST SYSTEM : Rodent - rat
【剂量/时间】 10 mg/kg
【参考】 IJCNAW International Journal of Cancer. (International Union Against Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland) V.1- 1966- Volume(issue)/page/year: 28,601,1981
【测试类型】 Unscheduled DNA synthesisTEST SYSTEM : Rodent - rat Cells - not otherwise specified
【剂量/时间】 100 umol/L
【参考】 ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 6,321,1984
【测试类型】 Unscheduled DNA synthesis
【接触途径】 IntraperitonealTEST SYSTEM : Rodent - rat
【剂量/时间】 100 mg/kg
【参考】 ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 7,889,1985
【测试类型】 Mutation test systems - not otherwise specifiedTEST SYSTEM : Rodent - rat Cells - not otherwise specified
【剂量/时间】 100 mmol/L
【参考】 RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970- Volume(issue)/page/year: 2,271,1971
【测试类型】 Mutation test systems - not otherwise specifiedTEST SYSTEM : Rodent - rat Liver
【剂量/时间】 100 mmol/L
【参考】 RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970- Volume(issue)/page/year: 2,271,1971
【测试类型】 Micronucleus test
【接触途径】 IntraperitonealTEST SYSTEM : Rodent - mouse
【剂量/时间】 20 mg/kg/48H (Intermittent)
【参考】 MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 389,3,1997
【测试类型】 Unscheduled DNA synthesisTEST SYSTEM : Rodent - mouse Liver
【剂量/时间】 10 umol/L
【参考】 CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 44,2918,1984
【测试类型】 DNA inhibitionTEST SYSTEM : Rodent - mouse Lymphocyte
【剂量/时间】 100 mmol/L
【参考】 RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970- Volume(issue)/page/year: 2,271,1971
【测试类型】 DNA adduct
【接触途径】 ParenteralTEST SYSTEM : Rodent - hamster
【剂量/时间】 3 mg/kg
【参考】 CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year: 16,65,1982
【测试类型】 DNA damage
【接触途径】 IntraperitonealTEST SYSTEM : Rodent - rat
【剂量/时间】 1 mg/kg
【参考】 CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 8,1033,1987
【测试类型】 DNA damage
【接触途径】 SubcutaneousTEST SYSTEM : Rodent - hamster
【剂量/时间】 10 mg/kg
【参考】 CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 9,1007,1988
【测试类型】 Unscheduled DNA synthesisTEST SYSTEM : Rodent - hamster Cells - not otherwise specified
【剂量/时间】 30 mg/L
【参考】 JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ. Volume(issue)/page/year: 71,523,1983
【测试类型】 DNA inhibitionTEST SYSTEM : Rodent - hamster Ovary
【剂量/时间】 100 mmol/L
【参考】 RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970- Volume(issue)/page/year: 2,271,1971

◇◇◇综述◇◇◇

IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 10,73,1976 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 10,73,1976 IARC Cancer Review:Group 2B IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 TOXICOLOGY REVIEW JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883- Volume(issue)/page/year: 172,1765,1960 TOXICOLOGY REVIEW 32XPAD "Teratology," Berry, C.L., and D.E. Poswillo, eds., New York, Springer, 1975 Volume(issue)/page/year: -,49,1975 TOXICOLOGY REVIEW CLPTAT Clinical Pharmacology and Therapeutics (St. Louis). (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1960- Volume(issue)/page/year: 5,480,1964 TOXICOLOGY REVIEW ARVPAX Annual Review of Pharmacology. (Palo Alto, CA) V.1-15, 1961-75. For publisher information, see ARPTDI. Volume(issue)/page/year: 5,447,1965 TOXICOLOGY REVIEW ADVPA3 Advances in Pharmacology. (New York, NY) V.1-6, 1962-68. For publisher information, see AVPCAQ. Volume(issue)/page/year: 4,263,1966

◇◇◇在美国的情况◇◇◇

EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat; SHE-clonal assay EPA GENETOX PROGRAM 1988, Positive: E coli polA without S9; Histidine reversion-Ames test EPA GENETOX PROGRAM 1988, Positive: TRP reversion

◇◇◇全部数据完毕◇◇◇

益母草	菊花
百合花	西洋参

115-02-6