医康传媒

◇◇◇化学鉴别信息◇◇◇

【RTECS 编号】 CG3325000
【化学名】 Arsenic trioxide
【CAS 登记号】 1327-53-3
【上次更新时间】 199712
【引用数据项】 81
【分子式】 As2-O3
【分子量】 197.84
【维斯韦塞(氏)线的符号】 AS2 O3
【化合物描述】 Agricultural Chemical Tumorigen Drug Mutagen Reproductive Effector Human
【别名】 * Acide arsenieux * Anhydride arsenieux * Arsenic blanc * Arsenic oxide * Arsenic(III) oxide * Arsenic sesquioxide * Arsenic trioxide * Arsenicum album * Arsenigen saure * Arsenious acid * Arsenious oxide * Arsenious trioxide * Arsenite * Arsenolite * Arsenous acid * Arsenous acid anhydride * Arsenous anhydride * Arsenous oxide * Arsenous oxide anhydride * Arsentrioxide * Arsodent * Claudelite * Claudetite * Crude arsenic * Diarsenic trioxide * RCRA waste number P012 * White arsenic

◇◇◇卫生公害数据◇◇◇

〖急性毒性数据〗

【测试类型】 LDLo - Lowest published lethal dose
【接触途径】 Oral
【测试物种】 Human - man
【剂量/时间】 29 mg/kg
【毒性作用】 Behavioral - sleep Behavioral - muscle weakness Gastrointestinal - hypermotility, diarrhea
【参考】 AEMED3 Annals of Emergency Medicine. (American College of Emergency Physicians, 1125 Executive Circle, Irving, TX 75038) Volume(issue)/page/year: 16,702,1987
【测试类型】 LDLo - Lowest published lethal dose
【接触途径】 Oral
【测试物种】 Human - man
【剂量/时间】 286 mg/kg
【毒性作用】 Cardiac - arrhythmias (including changes in conduction) Liver - liver function tests impaired Musculoskeletal - other changes
【参考】 JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.19- 1982- Volume(issue)/page/year: 29,45,1991
【测试类型】 LDLo - Lowest published lethal dose
【接触途径】 Oral
【测试物种】 Human
【剂量/时间】 1429 ug/kg
【毒性作用】 Details of toxic effects not reported other than lethal dose value
【参考】 YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950- Volume(issue)/page/year: 31,1247,1980
【测试类型】 LDLo - Lowest published lethal dose
【接触途径】 Oral
【测试物种】 Human - man
【剂量/时间】 2857 mg/kg
【毒性作用】 Behavioral - coma Liver - fatty liver degeneration Kidney, Ureter, Bladder - renal function tests depressed
【参考】 JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.19- 1982- Volume(issue)/page/year: 29,131,1991
【测试类型】 LDLo - Lowest published lethal dose
【接触途径】 Unreported
【测试物种】 Human - man
【剂量/时间】 2941 ug/kg
【毒性作用】 Details of toxic effects not reported other than lethal dose value
【参考】 85DCAI "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970 Volume(issue)/page/year: 2,73,1970
【测试类型】 LD50 - Lethal dose, 50 percent kill
【接触途径】 Oral
【测试物种】 Rodent - rat
【剂量/时间】 14600 ug/kg
【毒性作用】 Details of toxic effects not reported other than lethal dose value
【参考】 GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 52(1),21,1987
【测试类型】 LD50 - Lethal dose, 50 percent kill
【接触途径】 Intraperitoneal
【测试物种】 Rodent - rat
【剂量/时间】 871 mg/kg
【毒性作用】 Details of toxic effects not reported other than lethal dose value
【参考】 GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 19(3),30,1975
【测试类型】 LDLo - Lowest published lethal dose
【接触途径】 Subcutaneous
【测试物种】 Rodent - rat
【剂量/时间】 8 mg/kg
【毒性作用】 Skin and Appendages - corrosive (after topical exposure)
【参考】 JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 19,337,1922
【测试类型】 LDLo - Lowest published lethal dose
【接触途径】 Unreported
【测试物种】 Rodent - rat
【剂量/时间】 8 mg/kg
【毒性作用】 Details of toxic effects not reported other than lethal dose value
【参考】 BIZEA2 Biochemische Zeitschrift. (Berlin, Ger.) V.1-346, 1906-67. For publisher information, see EJBCAI. Volume(issue)/page/year: 184,360,1927
【测试类型】 LD50 - Lethal dose, 50 percent kill
【接触途径】 Oral
【测试物种】 Rodent - mouse
【剂量/时间】 31500 ug/kg
【毒性作用】 Details of toxic effects not reported other than lethal dose value
【参考】 CHYCDW Zhonghua Yufangyixue Zazhi. Chinese Journal of Preventive Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) Beginning history not known. Volume(issue)/page/year: 14,86,1980
【测试类型】 LD50 - Lethal dose, 50 percent kill
【接触途径】 Subcutaneous
【测试物种】 Rodent - mouse
【剂量/时间】 9800 ug/kg
【毒性作用】 Details of toxic effects not reported other than lethal dose value
【参考】 PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 78,392,1951
【测试类型】 LD50 - Lethal dose, 50 percent kill
【接触途径】 Intravenous
【测试物种】 Rodent - mouse
【剂量/时间】 10700 ug/kg
【毒性作用】 Details of toxic effects not reported other than lethal dose value
【参考】 PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 78,392,1951
【测试类型】 LDLo - Lowest published lethal dose
【接触途径】 Oral
【测试物种】 Mammal - dog
【剂量/时间】 10 mg/kg
【毒性作用】 Details of toxic effects not reported other than lethal dose value
【参考】 HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.) Volume(issue)/page/year: 4,1306,1935
【测试类型】 LDLo - Lowest published lethal dose
【接触途径】 Intradermal
【测试物种】 Mammal - dog
【剂量/时间】 2 mg/kg
【毒性作用】 Details of toxic effects not reported other than lethal dose value
【参考】 HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.) Volume(issue)/page/year: 4,1306,1935
【测试类型】 LD50 - Lethal dose, 50 percent kill
【接触途径】 Oral
【测试物种】 Rodent - rabbit
【剂量/时间】 20190 ug/kg
【毒性作用】 Details of toxic effects not reported other than lethal dose value
【参考】 CHYCDW Zhonghua Yufangyixue Zazhi. Chinese Journal of Preventive Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) Beginning history not known. Volume(issue)/page/year: 22,284,1988
【测试类型】 LDLo - Lowest published lethal dose
【接触途径】 Intravenous
【测试物种】 Rodent - rabbit
【剂量/时间】 10560 ug/kg
【毒性作用】 Lungs, Thorax, or Respiration - other changes Gastrointestinal - hypermotility, diarrhea Blood - other changes
【参考】 BIZEA2 Biochemische Zeitschrift. (Berlin, Ger.) V.1-346, 1906-67. For publisher information, see EJBCAI. Volume(issue)/page/year: 70,144,1915
【测试类型】 LDLo - Lowest published lethal dose
【接触途径】 Intradermal
【测试物种】 Bird - pigeon
【剂量/时间】 100 mg/kg
【毒性作用】 Details of toxic effects not reported other than lethal dose value
【参考】 HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.) Volume(issue)/page/year: 4,1306,1935
【测试类型】 LDLo - Lowest published lethal dose
【接触途径】 Intradermal
【测试物种】 Bird - chicken
【剂量/时间】 13 mg/kg
【毒性作用】 Details of toxic effects not reported other than lethal dose value
【参考】 HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.) Volume(issue)/page/year: 4,1306,1935
【测试类型】 LDLo - Lowest published lethal dose
【接触途径】 Oral
【测试物种】 Mammal - cattle
【剂量/时间】 30 mg/kg
【毒性作用】 Details of toxic effects not reported other than lethal dose value
【参考】 HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.) Volume(issue)/page/year: 4,1306,1935

〖其他多剂量毒性数据〗

【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Oral
【测试物种】 Rodent - rat
【剂量/时间】 900 mg/kg/15W-I
【毒性作用】 Behavioral - changes in motor activity (specific assay) Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death
【参考】 NTOTDY Neurobehavioral Toxicology and Teratology. (Fayetteville, NY) V.3-8, 1981-86. For publisher information, see NETEEC. Volume(issue)/page/year: 5,91,1983
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Oral
【测试物种】 Rodent - rat
【剂量/时间】 350 ug/kg/30D-I
【毒性作用】 Kidney, Ureter, Bladder - other changes in urine composition Nutritional and Gross Metabolic - changes in sodium Nutritional and Gross Metabolic - changes in potassium
【参考】 GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 52(1),21,1987
【测试类型】 TCLo - Lowest published toxic concentration
【接触途径】 Inhalation
【测试物种】 Rodent - rat
【剂量/时间】 31 ug/m3/24H/22W-C
【毒性作用】 Brain and Coverings - recordings from specific areas of CNS Blood - other changes
【参考】 GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 47(1),6,1982
【测试类型】 TCLo - Lowest published toxic concentration
【接触途径】 Inhalation
【测试物种】 Rodent - rat
【剂量/时间】 500 ug/m3/24H/33D-C
【毒性作用】 Brain and Coverings - recordings from specific areas of CNS Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase
【参考】 GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 47(11),74,1982

〖致肿瘤数据数据〗

【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Intratracheal
【测试物种】 Rodent - rat
【剂量/时间】 16 mg/kg/15W-I
【毒性作用】 Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors
【参考】 EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972- Volume(issue)/page/year: 19,191,1977
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Intratracheal
【测试物种】 Rodent - hamster
【剂量/时间】 45 mg/kg/15W-I
【毒性作用】 Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors
【参考】 ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.1- 1978- Volume(issue)/page/year: 7,403,1984
【测试类型】 TD - Toxic dose (other than lowest)
【接触途径】 Intratracheal
【测试物种】 Rodent - rat
【剂量/时间】 75 mg/kg/15W-I
【毒性作用】 Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors
【参考】 FKIZA4 Fukuoka Igaku Zasshi. (c/o Kyushu Daigaku Igakubu, Tatekasu, Fukuoka-shi, Fukuoka, Japan) V.33- 1940- Volume(issue)/page/year: 71,19,1980
【测试类型】 TD - Toxic dose (other than lowest)
【接触途径】 Intratracheal
【测试物种】 Rodent - hamster
【剂量/时间】 40 mg/kg/15W-I
【毒性作用】 Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors
【参考】 CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year: 21,141,1983
【测试类型】 TD - Toxic dose (other than lowest)
【接触途径】 Intratracheal
【测试物种】 Rodent - hamster
【剂量/时间】 55450 ug/kg/15W-I
【毒性作用】 Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors
【参考】 CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year: 21,141,1983
【测试类型】 TD - Toxic dose (other than lowest)
【接触途径】 Intratracheal
【测试物种】 Rodent - rat
【剂量/时间】 167 mg/kg/15W-I
【毒性作用】 Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors
【参考】 SAIGBL Sangyo Igaku. Japanese Journal of Industrial Health. (Nippon Sangyo Eisei Igakkai, Kosu Eisei Bldg., 1-29-8, Shinjuku, Shinjuku-ku, Tokyo 160, Japan) V.1- 1959- Volume(issue)/page/year: 20,230,1978
【测试类型】 TD - Toxic dose (other than lowest)
【接触途径】 Intratracheal
【测试物种】 Rodent - hamster
【剂量/时间】 39608 ug/kg/24W-I
【毒性作用】 Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors
【参考】 JOUOD4 Journal of UOEH (University of Occupational and Environmental Health). (Univ. of Occupational and Environmental Health, 1-1 Iseigaoka, Yahata-nishi-ku, Kitakyushu 807, Japan) V.1- 1979- Volume(issue)/page/year: 5(Suppl),109,1983
【测试类型】 TD - Toxic dose (other than lowest)
【接触途径】 Intratracheal
【测试物种】 Rodent - hamster
【剂量/时间】 55456 ug/kg/24W-I
【毒性作用】 Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors
【参考】 JOUOD4 Journal of UOEH (University of Occupational and Environmental Health). (Univ. of Occupational and Environmental Health, 1-1 Iseigaoka, Yahata-nishi-ku, Kitakyushu 807, Japan) V.1- 1979- Volume(issue)/page/year: 5(Suppl),109,1983
【测试类型】 TD - Toxic dose (other than lowest)
【接触途径】 Intratracheal
【测试物种】 Rodent - hamster
【剂量/时间】 30 mg/kg/15W-I
【毒性作用】 Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors
【参考】 SAIGBL Sangyo Igaku. Japanese Journal of Industrial Health. (Nippon Sangyo Eisei Igakkai, Kosu Eisei Bldg., 1-29-8, Shinjuku, Shinjuku-ku, Tokyo 160, Japan) V.1- 1959- Volume(issue)/page/year: 24,523,1982

〖繁殖数据〗

【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Oral
【测试物种】 Human - womanDOSE : 600 mg/kgSEX/DURATION : female 30 week(s) after conception
【毒性作用】 Reproductive - Effects on Newborn - Apgar score (human only) Reproductive - Effects on Newborn - other neonatal measures or effects
【参考】 AJDCAI American Journal of Diseases of Children. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1-80(3), 1911-50; V.100- 1960- Volume(issue)/page/year: 117,328,1969
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Oral
【测试物种】 Rodent - mouseDOSE : 224 mg/kgSEX/DURATION : multigenerations
【毒性作用】 Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)
【参考】 AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960- Volume(issue)/page/year: 23,102,1971
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Oral
【测试物种】 Rodent - mouseDOSE : 3636 mg/kgSEX/DURATION : female 1-18 day(s) after conception
【毒性作用】 Reproductive - Fertility - abortion
【参考】 52GUAX "Anorganische Stoffe in der Toxikologie and Kriminalistik, Symposium, Mosbach, Fed. Rep. Ger., 1983," Heppenheim, Fed. Rep. Ger., Verlag Dr. Dieter Helm, 1983 Volume(issue)/page/year: -,91,1983
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Oral
【测试物种】 Rodent - mouseDOSE : 8250 ug/kgSEX/DURATION : female 7-17 day(s) after conception
【毒性作用】 Reproductive - Specific Developmental Abnormalities - immune and reticuloendothelial system Reproductive - Effects on Newborn - behavioral
【参考】 CHYCDW Zhonghua Yufangyixue Zazhi. Chinese Journal of Preventive Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) Beginning history not known. Volume(issue)/page/year: 28,20,1994
【测试类型】 TDLo - Lowest published toxic dose
【接触途径】 Oral
【测试物种】 Rodent - mouseDOSE : 1650 ug/kgSEX/DURATION : female 7-17 day(s) after conception
【毒性作用】 Reproductive - Specific Developmental Abnormalities - Central Nervous System
【参考】 CHYCDW Zhonghua Yufangyixue Zazhi. Chinese Journal of Preventive Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) Beginning history not known. Volume(issue)/page/year: 28,20,1994
【测试类型】 TCLo - Lowest published toxic concentration
【接触途径】 Inhalation
【测试物种】 Rodent - mouseDOSE : 28500 ug/m3/4HSEX/DURATION : female 9-12 day(s) after conception
【毒性作用】 Reproductive - Effects on Embryo or Fetus - cytological changes (including somatic cell genetic material) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
【参考】 JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981- Volume(issue)/page/year: 5,61,1985
【测试类型】 TCLo - Lowest published toxic concentration
【接触途径】 Inhalation
【测试物种】 Rodent - mouseDOSE : 260 ug/m3/4HSEX/DURATION : female 9-12 day(s) after conception
【毒性作用】 Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
【参考】 JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981- Volume(issue)/page/year: 5,61,1985
〖致突变数据〗
【测试类型】 DNA repairTEST SYSTEM : Bacteria - Bacillus subtilis
【剂量/时间】 50 mmol/L
【参考】 MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 77,109,1980
【测试类型】 Unscheduled DNA synthesisTEST SYSTEM : Human Lung
【剂量/时间】 1 umol/L
【参考】 MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 315,11,1994
【测试类型】 DNA inhibitionTEST SYSTEM : Human HeLa cell
【剂量/时间】 500 umol/L
【参考】 MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 92,427,1982
【测试类型】 Cytogenetic analysisTEST SYSTEM : Human Leukocyte
【剂量/时间】 1200 nmol/L
【参考】 MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 88,73,1981
【测试类型】 Sister chromatid exchangeTEST SYSTEM : Human Lymphocyte
【剂量/时间】 2 ug/cm3
【参考】 BCTKAG Bromatologia i Chemia Toksykologiczna. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.4- 1971- Volume(issue)/page/year: 19,255,1986
【测试类型】 Micronucleus test
【接触途径】 IntraperitonealTEST SYSTEM : Rodent - mouse
【剂量/时间】 1 mg/kg
【参考】 GNKAA5 Genetika (Moscow). For English translation, see SOGEBZ. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) No.1- 1965- Volume(issue)/page/year: 20,365,1984
【测试类型】 DNA inhibition
【接触途径】 OralTEST SYSTEM : Rodent - mouse
【剂量/时间】 20 mL/kg
【参考】 ARGEAR Archiv fuer Geschwulstforschung. (VEB Verlag Volk und Gesundheit Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1949- Volume(issue)/page/year: 51,605,1981
【测试类型】 Cytogenetic analysis
【接触途径】 OralTEST SYSTEM : Rodent - mouse
【剂量/时间】 3696 mg/kg
【参考】 CYTOAN Cytologia. (Japan Pub. Trading Co. (USA), 1255 Howard St., San Francisco, CA 94103) V.1- 1929- Volume(issue)/page/year: 52,445,1987
【测试类型】 Cytogenetic analysisTEST SYSTEM : Rodent - mouse Cells - not otherwise specified
【剂量/时间】 28500 ug/m3
【参考】 JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981- Volume(issue)/page/year: 5,61,1985

◇◇◇综述◇◇◇

IARC Cancer Review:Human Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 2,48,1973 IARC Cancer Review:Human Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 23,39,1980 IARC Cancer Review:Animal Limited Evidence IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,100,1987 IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 2,48,1973 IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 23,39,1980 IARC Cancer Review:Group 1 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,100,1987 TOXICOLOGY REVIEW AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU. Volume(issue)/page/year: 21,132,1960 TOXICOLOGY REVIEW ADTEAS Advances in Teratology. (New York, NY) V.1-5, 1966-72. Discontinued. Volume(issue)/page/year: 5,51,1972 TOXICOLOGY REVIEW PTPAD4 Pharmacology and Therapeutics, Part A: Chemotherapy, Toxicology and Metabolic Inhibitors. (Oxford, UK) V.1-2, 1976-78. For publisher information, see PHTHDT. Volume(issue)/page/year: 1,189,1976 TOXICOLOGY REVIEW 85DHAX "Medical and Biologic Effects of Environmental Pollutants Series," Washington, DC, National Academy of Sciences, 1972-77 Volume(issue)/page/year: As,-,1977

◇◇◇美国标准和规章◇◇◇

EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 OSHA-cancer hazard CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1018,1987

◇◇◇职业接触限量◇◇◇

OEL-AUSTRALIA;Carcinogen JAN 1993 OEL-BELGIUM;Carcinogen JAN 1993 OEL-FINLAND;Carcinogen JAN 1993 OEL-FRANCE:STEL 0.2 ppm;Carcinogen JAN 1993 OEL-GERMANY;Carcinogen JAN 1993 OEL-JAPAN:STEL 0.5 ppm;Carcinogen JAN 1993 OEL-THE PHILIPPINES:TWA 0.1 mg/m3;Carcinogen JAN 1993 OEL-SWITZERLAND:TWA 0.15 mg/m3 JAN 1993 OEL-UNITED KINGDOM:TWA 0.1 mg/m3 JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV

◇◇◇NIOSH 标准发展和监测数据◇◇◇

【参考】 NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992
【NIOSH 职业性接触鉴定数据】 NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 07570 No. of Facilities: 1284 (estimated) No. of Industries: 6 No. of Occupations: 6 No. of Employees: 3980 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 07570 No. of Facilities: 107 (estimated) No. of Industries: 8 No. of Occupations: 16 No. of Employees: 4657 (estimated) No. of Female Employees: 2001 (estimated)

◇◇◇在美国的情况◇◇◇

EPA GENETOX PROGRAM 1988, Positive: B subtilis rec assay EPA TSCA Section 8(b) CHEMICAL INVENTORY EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998 NIOSH CURRENT INTELLIGENCE BULLETIN 14, 1976 NIOSH Analytical Method, 1994: Arsenic trioxide as As, 7901 NTP 7th Annual Report on Carcinogens, 1992 : known to be carcinogenic NTP Carcinogenesis studies; selected, October 1997

◇◇◇全部数据完毕◇◇◇

益母草	菊花
百合花	西洋参

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