- 【药物名称】Carazolol, BM-51052
- 【化学名】1-(9H-Carbazol-4-yloxy)-3-(isopropylamino)-2-propanol
- 【CAS登记号】57775-29-8
- 【结构式】
- 【分子式】C18-H22-N2-O2
- 【分子量】298.3838
- 【原研厂家】
- 【作用类别】
- 【研发状态】Not Determined
- 【合成情况】
- 〖来源〗Drugs Fut
- 〖合成路线〗
- 〖标题〗Carazolol
- 〖合成方法〗By condensation of 4-hydroxycarbazole (I) with epichlorohydrin (II) by means of NaOH in aqueous dioxane at 40 C to yield 4-(2,3-epoxypropoxy)carbazole (III), followed by treatment with isopropylamine (IV) in refluxing ethanol
- 〖作者〗Weetman, D.F.; Castaer, J.
- 〖参考〗Weetman, D.F.; Castaer, J.; Carazolol. Drugs Fut 1977, 2, 11, 715
- 〖出处〗Drugs Fut1977,2,(11):715
- 〖备注〗Synthesis By condensation of 4-hydroxycarbazole (I) with epichiorohydrin (II) by means of NaOH in aqueous dioxane at 40 C to yield 4-(2,3-epoxypropoxy)carbazole (III), followed by treatment with isopropylamine (IV) in refluxing ethanol (1). Manufacturer Boehringer Mannheim G.m.b.H. Reference 1. Leinert, H. et al. (Boehringer Mannheim G.m.b.H.); DE 2240599
- 〖来源〗CH 598216; DE 2240599; FR 2196165; GB 1369580; JP 49056973
- 〖合成路线〗
- 〖标题〗Triyclic diphenylamines derivatives
- 〖合成方法〗By condensation of 4-hydroxycarbazole (I) with epichlorohydrin (II) by means of NaOH in aqueous dioxane at 40 C to yield 4-(2,3-epoxypropoxy)carbazole (III), followed by treatment with isopropylamine (IV) in refluxing ethanol
- 〖作者〗Leinert, H.; et al. (Boehringer Ingelheim GmbH)
- 〖参考〗Leinert, H.; et al. (Boehringer Ingelheim GmbH); Triyclic diphenylamines derivatives. CH 598216; DE 2240599; FR 2196165; GB 1369580; JP 49056973
- 〖出处〗CH 598216; DE 2240599; FR 2196165; GB 1369580; JP 49056973,,():
- 〖备注〗
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