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Sofalcone,64506-49-6,C27-H30-O6,2-[5-(3-Methyl-2-butenyloxy)

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摘 要：Sofalcone,64506-49-6,C27-H30-O6,2-[5-(3-Methyl-2-butenyloxy)-2-[3-[4-(3-methyl-2-butenyloxy)phenyl]-2(E)-propenoyl]phenoxy]acetic acid
  • 【药物名称】Sofalcone
  • 【化学名】2-[5-(3-Methyl-2-butenyloxy)-2-[3-[4-(3-methyl-2-butenyloxy)phenyl]-2(E)-propenoyl]phenoxy]acetic acid
  • 【CAS登记号】64506-49-6
  • 【结构式】Sofalcone,64506-49-6,C27-H30-O6,2-[5-(3-Methyl-2-butenyloxy)--药物合成数据库
  • 【分子式】C27-H30-O6
  • 【分子量】450.528
  • 【原研厂家】Taisho (Originator)
  • 【作用类别】Antiulcer Drugs, GASTROINTESTINAL DRUGS
  • 【研发状态】Preclinical
  • 【合成情况】　
  • 〖来源〗Drugs Fut
  • 〖合成路线〗
  • 〖标题〗SU-88
  • 〖合成方法〗The reaction of 2-hydroxy-4-(3-methyl-2-butenyloxy)acetophenone (I) with ethyl bromoacetate (II) by means of KOH in acetone gives 2-ethoxycarbonylmethoxy-4-(3-methyl-2-butenyloxy)acetophenone (III), which is then condensed with 4-(3-methyl-2-butenyloxy)benzaldehyde (IV) by means of KOH in ethanol.
  • 〖作者〗Grau, M.; Castaer, J.; Blancafort, P.; Serradell, M.N.
  • 〖参考〗Grau, M.; Castaer, J.; Blancafort, P.; Serradell, M.N.; SU-88. Drugs Fut 1983, 8, 6, 513
  • 〖出处〗Drugs Fut1983,8,(6):513
  • 〖备注〗Synthesis of SU-88 (EN:070203) The reaction of 2-hydroxy-4-(3-methyl-2-butenyloxy)acetophenone (I) with ethyl bromoacetate (II) by means of KOH in acetone gives 2-ethoxycarbonylmethoxy-4-(3-methyl-2-butenyloxy)acetophenone (III), which is then condensed with 4-(3-methyl-2-butenyloxy)benzaldehyde (IV) by means of KOH in ethanol (1). (Scheme 07020301a) Description Crystals, m.p. 141-2?(1). Manufacturer Taisho Pharm. Co., Ltd. (Japan). Reference 1. Kyogoku, K., Hatayama, K., Yokomori, S., Sawada, J. and Tanaka, I. (Taisho Pharm. Co., Ltd.); US 4085135.
  • 〖来源〗DE 2705603; ES 455620; FR 2340924; GB 1523241; JP 52097950; US 4085135
  • 〖合成路线〗
  • 〖标题〗2-(Carboxymethoxy)chalcones
  • 〖合成方法〗The reaction of 2-hydroxy-4-(3-methyl-2-butenyloxy)acetophenone (I) with ethyl bromoacetate (II) by means of KOH in acetone gives 2-ethoxycarbonylmethoxy-4-(3-methyl-2-butenyloxy)acetophenone (III), which is then condensed with 4-(3-methyl-2-butenyloxy)benzaldehyde (IV) by means of KOH in ethanol.
  • 〖作者〗Kyogoku, K.; Hatayama, K.; Yokomori, S.; Sawada, J.; Tanaka, I. (Taisho Pharmaceutical Co., Ltd.)
  • 〖参考〗Kyogoku, K.; Hatayama, K.; Yokomori, S.; Sawada, J.; Tanaka, I. (Taisho Pharmaceutical Co., Ltd.); 2-(Carboxymethoxy)chalcones. DE 2705603; ES 455620; FR 2340924; GB 1523241; JP 52097950; US 4085135
  • 〖出处〗DE 2705603; ES 455620; FR 2340924; GB 1523241; JP 52097950; US 4085135,,():
  • 〖备注〗
 
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