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,C11H11N5O3,261.2420,5-(2-Methylpyridin-5-yl)-2-(nitroamino)

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摘 要：,C11H11N5O3,261.2420,5-(2-Methylpyridin-5-yl)-2-(nitroamino)pyrimidin-4(3H)-one
  • 【化学名】5-(2-Methylpyridin-5-yl)-2-(nitroamino)pyrimidin-4(3H)-one
  • 【CAS登记号】
  • 【结构式】,C11H11N5O3,261.2420,5-(2-Methylpyridin-5-yl)-2-(nitroamino)--药物合成数据库
  • 【分子式】C11H11N5O3
  • 【分子量】261.2420
  • 【来源】
  • 【合成情况】　
  • 〖目标产物〗Lupitidine hydrochloride, SK&F-93479
  • 〖合成路线〗
  • 〖合成方法〗A new synthesis of lupitidine has been described: The condensation of 5-(2-methylpyridin-5-yl)-2-(nitroamino)pyrimidin-4(3H)-one (I) with 2-(2-furylmethylthio)ethylamine (II) in refluxing pyridine gives 2-[2-(2-furylmethylthio)ethylamino]-5-(2-methylpyridin-5-ylmethyl)pyrimidin-4(3H)-one (III), which is then submitted to a conventional Mannich condensation with formaldehyde and dimethylamine in acetic acid.
  • 〖参考〗Parsons, M.E.; Rawlings, D.A.; Ife, R.J.; Brown, T.H.; Blakemore, R.C.; Blurton, P.; Armitage, M.A.; Durant, G.J.; Slingsby, B.P.; Ganellin, C.R.; Isocytosine H2-receptor histamine antagonists. III. The synthesis and biological activity of lupitidine (SK&hemdrug.com/file/upload/SYNTHESIS??缙??Parsons, M.E.; Rawlings,
 
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