- 【化学名】2-[(2-Furylmethyl)sulfanyl]-1-ethanamine; 2-[(2-Furylmethyl)sulfanyl]ethylamine; 2-(2-Aminoethyl) furfuryl thiol ether
- 【CAS登记号】36415-21-1
- 【结构式】
![36415-21-1,C7H11NOS,157.2358,2-[(2-Furylmethyl)sulfanyl]-1-e--药物合成数据库](/file/upload/SYNTHESIS/STR/100/10002.gif)
- 【分子式】C7H11NOS
- 【分子量】157.2358
- 【来源】Davos Chemical Corporation; TCI
- 【合成情况】
- 〖目标产物〗Lupitidine hydrochloride, SK&F-93479
- 〖合成路线〗
- 〖合成方法〗A new synthesis of lupitidine has been described: The condensation of 5-(2-methylpyridin-5-yl)-2-(nitroamino)pyrimidin-4(3H)-one (I) with 2-(2-furylmethylthio)ethylamine (II) in refluxing pyridine gives 2-[2-(2-furylmethylthio)ethylamino]-5-(2-methylpyridin-5-ylmethyl)pyrimidin-4(3H)-one (III), which is then submitted to a conventional Mannich condensation with formaldehyde and dimethylamine in acetic acid.
- 〖参考〗Parsons, M.E.; Rawlings, D.A.; Ife, R.J.; Brown, T.H.; Blakemore, R.C.; Blurton, P.; Armitage, M.A.; Durant, G.J.; Slingsby, B.P.; Ganellin, C.R.; Isocytosine H2-receptor histamine antagonists. III. The synthesis and biological activity of lupitidine (SK&rmitage, M.A.; Durant, G.J.; Slin?缙eh?`P.; Ganellin, C.R.; Is
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