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,C4H8O2S,120.1712,1-Hydroxy-1-(methylsulfanyl)acetone

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摘 要：,C4H8O2S,120.1712,1-Hydroxy-1-(methylsulfanyl)acetone
  • 【化学名】1-Hydroxy-1-(methylsulfanyl)acetone
  • 【CAS登记号】
  • 【结构式】,C4H8O2S,120.1712,1-Hydroxy-1-(methylsulfanyl)acetone--药物合成数据库
  • 【分子式】C4H8O2S
  • 【分子量】120.1712
  • 【来源】
  • 【合成情况】　
  • 〖目标产物〗Mitoguazone, Win-10708-2, NSC-30609(acetate), NSC-32946(diHCl), MGBG, Methyl-GAG, Zyrkamine
  • 〖合成路线〗
  • 〖合成方法〗The synthesis of [14C]-mitoguazone has been reported: The methylation of [14C]-labeled potassium acetate (I) with dimethyl sulfate in HMPT gives the corresponding ester (II), which by reaction with the sodium salt of dimethylsulfoxide (III) in DMSO affords the hemithioketal (IV). Finally, this compound is condensed with aminoguanidine (V) in DMSO/water.
  • 〖参考〗Burgos, A.; Ellames, G.J.; Convenient synthesis of [2-C-14]-methylglyoxal bis(guanylhydrazone), [C-14]-mitoguazone. J Label Compd Radiopharm 1995, 36, 1, 93
 
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