阿法替尼杂质（Afatinib）

名称

CAS

化学名称

阿法替尼中间体(http://www.chemdrug.com/sell/19/)A1

314771-76-1

N4-(3-Chloro-4-fluorophenyl)-7-[[(3S)-tetrahydro-3-furanyl]oxy]-4,6-quinazolinediamine

阿法替尼中间体A2

314771-76-1

N4-(3-Chloro-4-fluorophenyl)-7-[[(3S)-tetrahydro-3-furanyl]oxy]-4,6-quinazolinediamine

阿法替尼中间体B

162012-67-1

N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine

阿法替尼杂质C

NA

(S)-2-((4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)amino)-2-oxoacetic acid

阿法替尼杂质D

N/A

(S)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)but-3-enamide

阿法替尼杂质E

N/A

N-(4-((3-chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-2-(oxiran-2-yl)acetamide

阿法替尼杂质F

N/A

(S,E)-4-((4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)amino)-N,N-dimethyl-4-oxobut-2-en-1-amine oxide

阿法替尼杂质G

NA

(E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-fluoroquinazolin-6-yl)-4-(dimethylamino)but-2-enamide

阿法替尼杂质H

NA

(S)-N4-(3-chloro-4-fluorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine

阿法替尼杂质I

NA

(R)-N4-(3,4-dichlorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine

阿法替尼杂质J

N/A

(S,E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-hydroxybut-3-enamide

阿法替尼杂质K

NA

(S,E)-4-(dimethylamino)-N-(4-((4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)but-2-enamide

阿法替尼杂质L

NA

(R)-N4-(3,4-difluorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine

阿法替尼杂质M

NA

(R)-N4-(4-chloro-3-fluorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine

阿法替尼杂质N

850140-72-6

(2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide

阿法替尼杂质O

439081-18-2

(S,E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide

阿法替尼杂质P1

314771-88-5

4-QuinazolinaMine, N-(3-chloro-4-fluorophenyl)-6-nitro-7-[[(3S)-tetrahydro-3-furanyl]oxy]-

阿法替尼杂质P2

314771-88-5

4-QuinazolinaMine, N-(3-chloro-4-fluorophenyl)-6-nitro-7-[[(3S)-tetrahydro-3-furanyl]oxy]-

阿法替尼杂质Q

179552-73-9

7-Chloro-N-(3-chloro-4-fluorophenyl)-6-nitro-4-quinazolinamine

阿法替尼杂质R

53449-14-2

7-Chloro-6-nitro-4-hydroxyquinazoline

阿法替尼杂质S

NA

(S,E)-N-(4-((4-chloro-3-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide

阿法替尼杂质T

NA

(R,E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide

阿法替尼杂质ZC

NA

(R,E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide

阿法替尼杂质ZD

NA

(R,E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetra- hydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino) but-2-enamide

阿法替尼杂质ZG1

NA

(S,E)-N-(4-((3,4-dichlorophenyl)amino)-7-((tetrahydrof uran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2- enamide

阿法替尼杂质ZG2

NA

(S,E)-N-(4-((3,4-dichlorophenyl)amino)-7-((tetrahydrof uran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2- enamide

阿法替尼杂质ZH1

NA

(S,E)-N-(4-((3,4-difluorophenyl)amino)-7-((tetrahydro- furan-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2 -enamide

阿法替尼杂质ZH2

NA

(S,E)-N-(4-((3,4-difluorophenyl)amino)-7-((tetrahydro- furan-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2 -enamide

阿法替尼杂质ZH

NA

(S,E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)but-2-enamide

阿法替尼杂质ZG

NA

(S,E)-N-(4-((4-chloro-3-fluorophenyl)amino)-7-((tetra- hydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino) but-2-enamid

阿法替尼杂质ZI

NA

(S,E)-4-bromo-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)but-2-enamide

阿法替尼杂质ZJ

NA

(R,E)-4-(dimethylamino)-N-(4-hydroxy-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)but-2-enamide

阿法替尼杂质ZK

NA

(R,E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(methylamino)but-2-enamide

阿法替尼杂质ZL

NA

(S,E)-4-((4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)amino)-N,N-dimethyl-4-oxobut-2-en-1-amine oxide

双马来酸阿法替尼

850140-72-6

(S,E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide dimaleate